What is the clinical use of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester)?

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Last updated: February 28, 2025View editorial policy

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From the Research

Noopept is a synthetic nootropic compound that may enhance cognitive function, memory, and learning ability, and its clinical use is primarily focused on improving cognitive impairment in patients with stroke or other neurological conditions, with a typical dosage ranging from 10-30mg taken 1-3 times daily 1. The most recent and highest quality study on Noopept was published in 2021, which explored the development of a dissolving microneedle patch loaded with ultradeformable liposomes encapsulated Noopept for the management of dementia 2. This study demonstrated a 6.5-fold increase in steady state flux across full thickness pig ear skin and a 3-fold increase in relative bioavailability compared to oral Noopept suspension.

Key Points to Consider

  • Noopept is not FDA-approved for medical use in the United States, and research on its long-term effects is limited 3, 4.
  • Potential side effects of Noopept include headaches, irritability, and insomnia, particularly at higher doses 4.
  • Noopept works by potentially increasing brain-derived neurotrophic factor (BDNF) levels and modulating glutamate receptors, which may support neuroplasticity and cognitive function 5.
  • If considering Noopept, it's advisable to consult with a healthcare provider first, especially if you have existing health conditions or take other medications, as drug interactions are possible 1, 2.

Clinical Use and Dosage

  • The typical dosage of Noopept ranges from 10-30mg taken 1-3 times daily, with many users starting at the lower end and adjusting as needed 1, 2.
  • Noopept is rapidly absorbed when taken orally and should be taken with food to improve absorption 5.
  • Effects of Noopept typically begin within 15-30 minutes and last for several hours 4, 2.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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