From the FDA Drug Label
ADVERSE REACTIONS ... hypothermia; Yes, Lorazepam (Ativan) can cause hypothermia 1.
From the Research
Yes, Ativan (lorazepam) can potentially cause hypothermia as a side effect, particularly when used in combination with other central nervous system depressants or in vulnerable populations. Ativan belongs to the benzodiazepine class of medications which can affect the body's temperature regulation mechanisms by depressing the central nervous system 2. This effect is more likely to occur with higher doses or in vulnerable populations such as elderly patients, those with compromised health status, or when Ativan is combined with other central nervous system depressants like alcohol or opioids.
The risk of hypothermia increases during prolonged use or in overdose situations. Hypothermia from Ativan may present as an abnormally low body temperature (below 95°F or 35°C), along with symptoms like shivering, confusion, slurred speech, slow breathing, and drowsiness. If someone taking Ativan experiences these symptoms, especially in a normal temperature environment, they should seek immediate medical attention.
Some studies suggest that the use of benzodiazepines, such as lorazepam, can increase the risk of hypothermia, particularly when used in combination with antipsychotic medications 3, 4, 5. However, the most relevant study to this question is a case report of non-fatal mirtazapine overdose, which highlights the potential for lorazepam to contribute to hypothermia in overdose situations 2.
Patients should be monitored for temperature changes when starting Ativan therapy, particularly those at higher risk, and should be advised to maintain normal environmental temperatures and appropriate clothing. It is essential to prioritize the patient's safety and take preventive measures to avoid hypothermia, especially in high-risk populations.
Key points to consider:
- Ativan can cause hypothermia, especially in vulnerable populations or when used in combination with other central nervous system depressants
- Monitor patients for temperature changes, especially during the initial stages of treatment or when increasing the dose
- Advise patients to maintain normal environmental temperatures and wear appropriate clothing
- Seek immediate medical attention if symptoms of hypothermia occur, such as shivering, confusion, or slow breathing.