From the FDA Drug Label
WARNINGS Visual Symptons Patients should be advised that blurring or other visual symptoms such as spots or flashes (scintillating scotomata) may occasionally occur during therapy with clomiphene citrate. A study patient taking 200 mg clomiphene citrate daily developed visual blurring on the 7th day of treatment, which progressed to severe diminution of visual acuity by the 10th day.
Yes, Enclomiphene (Clomid) can cause blurred vision. Patients should be warned that these visual symptoms may render such activities as driving a car or operating machinery more hazardous than usual, particularly under conditions of variable lighting 1.
From the Research
Yes, enclomiphene (Clomid) can cause blurred vision as a side effect, and patients should be aware of this potential risk when taking the medication. This visual disturbance typically occurs in about 1-2% of patients taking these medications and is usually temporary, resolving after discontinuation of the drug 2. The visual changes happen because these medications can affect the retina and optic pathways. Clomiphene and enclomiphene bind to estrogen receptors in the visual system, potentially causing changes in visual perception.
Key Points to Consider
- If you experience blurred vision while taking either medication, you should contact your healthcare provider immediately.
- Do not drive or operate heavy machinery if you're experiencing visual disturbances.
- Your doctor may recommend stopping the medication or reducing the dosage, depending on the severity of symptoms.
- Most visual side effects resolve within a few days to weeks after stopping the medication, but in rare cases, they can persist longer.
- Other visual disturbances that might occur include light sensitivity, seeing spots or flashes, or difficulty with night vision.
Relevant Evidence
The study by 2 highlights the potential for clomiphene citrate to cause persistent visual abnormalities, including blurred vision, in some patients. Although this study is older, its findings are still relevant today, and it is essential to consider the potential risks of blurred vision when prescribing enclomiphene or clomiphene citrate. More recent studies, such as 3, also discuss the importance of recognizing and managing ocular adverse effects associated with systemic medications, including those that can cause blurred vision.
Clinical Implications
In clinical practice, it is crucial to weigh the benefits of enclomiphene or clomiphene citrate against the potential risks, including blurred vision. Patients should be informed about the possible side effects and monitored closely for any visual disturbances. If blurred vision occurs, the medication should be stopped or the dosage reduced, and the patient should be referred to an ophthalmologist for further evaluation and management.