From the Research
Safety of Saffron for Pediatric Use
- The safety of saffron for pediatric use has been evaluated in several studies, with varying results.
- A study published in 2018 found that a standardized extract of saffron (affron®) was well-tolerated and effective in reducing anxiety and depressive symptoms in youth aged 12-16 years 1.
- Another study published in 2022 found that saffron extract (Saffr'Activ) was effective in treating Attention Deficit/Hyperactivity Disorder (ADHD) in children and adolescents, with efficacy comparable to that of methylphenidate 2.
- However, a study published in 2014 found that high doses of saffron may have nephrotoxic effects on neonates of lactating mothers, although the spice was considered "nearly safe" at lower doses 3.
- The bioactive constituents of saffron, such as apocarotenoids, monoterpenoids, flavonoids, phenolic acids, and phytosterols, have been widely investigated for their therapeutic effects, including neuroprotective, anxiolytic, antidepressant, learning, and memory-enhancing effects 4, 5.
Potential Risks and Benefits
- The potential benefits of saffron for pediatric use include its antioxidant, anti-inflammatory, and neuroprotective effects, which may be beneficial for treating various neurological and psychiatric disorders.
- However, the potential risks of saffron for pediatric use include nephrotoxicity and hepatotoxicity at high doses, as well as the potential for interactions with other medications.
- Further research is needed to fully evaluate the safety and efficacy of saffron for pediatric use, particularly in terms of its long-term effects and potential interactions with other medications.
- Studies have shown that saffron and its compounds have high bioavailability and bioaccessibility, and the ability to pass the blood-brain barrier, which may contribute to its therapeutic effects 5.