Differential Diagnosis for Rash in Palms and Soles with Eosinophilia
- Single Most Likely Diagnosis
- Palmoplantar Pustulosis: This condition is characterized by the presence of sterile pustules on the palms and soles, often accompanied by eosinophilia. It is a common cause of palmoplantar rash and the presence of eosinophilia supports this diagnosis.
- Other Likely Diagnoses
- Dyshidrotic Eczema (Pompholyx): A type of eczema that affects the palms and soles, characterized by small, itchy blisters. Eosinophilia can be present, especially if there is an allergic component.
- Scabies: A parasitic infection caused by the mite Sarcoptes scabiei, which can lead to a rash on the palms and soles, along with eosinophilia due to the body's immune response.
- Contact Dermatitis: An allergic or irritant reaction to substances that come into contact with the skin, which can cause a rash on the palms and soles. Eosinophilia may be present, particularly in allergic contact dermatitis.
- Do Not Miss Diagnoses
- Acute HIV Infection: Some patients with acute HIV infection can present with a rash on the palms and soles, accompanied by eosinophilia. Missing this diagnosis could have significant consequences.
- Syphilis (Secondary): Secondary syphilis can cause a rash on the palms and soles, along with various other symptoms. Eosinophilia may be present, and missing this diagnosis could lead to serious complications if left untreated.
- Rare Diagnoses
- Erythema Multiforme: A skin condition characterized by target lesions, which can occasionally affect the palms and soles. Eosinophilia may be present, especially if there is an infectious or allergic trigger.
- Keratoderma Blennorrhagicum: A rare condition associated with reactive arthritis, characterized by a rash on the palms and soles. Eosinophilia can occur, particularly if there is an underlying infection.