What are the contraindications for Aldactone (spironolactone)?

Contraindications for Aldactone (Spironolactone)

Aldactone (spironolactone) is absolutely contraindicated in patients with hyperkalemia, Addison's disease, and those taking eplerenone concurrently. 1

Absolute Contraindications

• Hyperkalemia (serum potassium >5.0 mEq/L) 2, 1
• Addison's disease 1
• Concurrent use of eplerenone (another aldosterone antagonist) 1
• Severe renal dysfunction:
  • Serum creatinine >2.5 mg/dL in men
  • Serum creatinine >2.0 mg/dL in women
  • eGFR <30 mL/min/1.73 m² 2

Relative Contraindications and Caution Required

Medication Combinations with High Risk

• Concomitant use of potassium supplements 2
• Concomitant use of other potassium-sparing diuretics 2
• Combined use of ACE inhibitors AND ARBs with spironolactone (triple therapy) 2
• High-dose ACE inhibitors (e.g., captopril ≥75 mg daily; enalapril or lisinopril ≥10 mg daily) 2
• Potent CYP3A4 inhibitors 2
• NSAIDs and COX-2 inhibitors (increase risk of hyperkalemia and renal dysfunction) 2

High-Risk Patient Populations

• Elderly patients (particularly those >75 years) 3, 4
• Diabetes mellitus 2, 3
• Liver disorders 2
• Patients at risk for dehydration 3
• Worsening heart failure 3
• Patients with LVEF <20% (require extra monitoring) 4

Monitoring Requirements

Before Initiation

• Check renal function and serum electrolytes 2
• Ensure serum potassium <5.0 mEq/L 2
• Ensure serum creatinine ≤2.5 mg/dL in men or ≤2.0 mg/dL in women 2
• Ensure eGFR >30 mL/min/1.73 m² 2

After Initiation

• Recheck renal function and serum electrolytes at:
  • 2-3 days after starting 2
  • 7 days after starting 2
  • Monthly for first 3 months 2
  • Every 3 months thereafter 2
• More frequent monitoring for high-risk patients 4

Management of Complications

Hyperkalemia

• If K⁺ rises to >5.5 mmol/L: Halve dose (e.g., to 25 mg on alternate days) 2
• If K⁺ rises to ≥6.0 mmol/L: Stop spironolactone immediately 2, 3

Worsening Renal Function

• If creatinine rises to >220 μmol/L (2.5 mg/dL): Halve dose 2
• If creatinine rises to >310 μmol/L (3.5 mg/dL): Stop spironolactone immediately 2

Other Side Effects

• For breast tenderness/enlargement in men: Consider switching to eplerenone 2, 5

Practical Prescribing Points

• Starting dose should be 12.5-25 mg daily 2
• For patients with concerns about hyperkalemia or marginal renal function (eGFR 30-49 mL/min/1.73 m²), consider every-other-day dosing 2
• Discontinue potassium supplementation when starting spironolactone 2, 4
• Daily doses exceeding 25 mg significantly increase hyperkalemia risk 3, 6
• Monitor body weight changes closely as they may indicate fluid status changes 4

Common Pitfalls to Avoid

• Failing to discontinue potassium supplements when initiating spironolactone
• Not monitoring renal function and electrolytes frequently enough in high-risk patients
• Using doses >25 mg daily in elderly patients or those with compromised renal function
• Combining with ACE inhibitors and ARBs simultaneously
• Not recognizing early signs of hyperkalemia or renal dysfunction

The risk-benefit ratio of spironolactone must be carefully considered, particularly in elderly patients and those with multiple comorbidities, as real-world studies show significantly higher rates of hyperkalemia and renal dysfunction than reported in clinical trials 4.