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Last updated: July 18, 2025View editorial policy

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Differential Diagnosis for Postpartum Calf Pain and Swelling

  • Single most likely diagnosis
    • A) Hypercoagulable state of pregnancy: This is the most likely cause due to the increased risk of deep vein thrombosis (DVT) in the postpartum period, especially after an uncomplicated labor and delivery. The symptoms of pain, cramping, swelling, and tenderness with dorsiflexion of the right calf are classic for DVT.
  • Other Likely diagnoses
    • E) Prolonged pressure on the vena cava during delivery: This could lead to venous stasis and potentially cause a DVT, although it is less likely than the hypercoagulable state of pregnancy.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Peripheral artery aneurysm or embolus (options C and D): Although less likely, these conditions could lead to severe complications, including limb loss or death, if not promptly diagnosed and treated.
  • Rare diagnoses
    • B) Hyperuricemia: This condition is more commonly associated with gout and is unlikely to cause the symptoms described in this scenario. However, it could potentially contribute to renal insufficiency or other complications in the postpartum period, but it is not directly related to the calf pain and swelling.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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