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Last updated: July 20, 2025View editorial policy

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Differential Diagnosis for Axillary Lymphadenopathy and Erythema

Single Most Likely Diagnosis

  • Cat Scratch Disease: This is a common condition caused by Bartonella henselae, transmitted through cat scratches or bites, leading to axillary lymphadenopathy and sometimes erythema at the site of the scratch.

Other Likely Diagnoses

  • Breast Cancer: Axillary lymphadenopathy can be a sign of breast cancer, especially if there's a palpable mass or other symptoms like nipple discharge. Erythema might be seen in inflammatory breast cancer.
  • Infectious Causes (e.g., Staphylococcus aureus, Streptococcus pyogenes): Bacterial infections can cause lymphadenopathy and erythema, particularly if there's an abscess or cellulitis in the axillary region.
  • Lymphoma: Although less common, lymphoma can present with lymphadenopathy, and erythema might be seen if there's skin involvement.

Do Not Miss Diagnoses

  • Breast Abscess: An abscess in the breast tissue can cause axillary lymphadenopathy and significant erythema. It's crucial to diagnose and treat promptly to avoid complications.
  • Necrotizing Fasciitis: A severe infection that can cause erythema, swelling, and sometimes lymphadenopathy. It's a medical emergency requiring immediate attention.
  • Inflammatory Breast Cancer: A rare and aggressive form of breast cancer that presents with rapid onset of erythema, edema, and warmth of the breast skin, often without a distinct lump.

Rare Diagnoses

  • Kikuchi-Fujimoto Disease: A rare, self-limiting condition that causes lymphadenopathy, often in the neck but can be axillary, and might be accompanied by systemic symptoms.
  • Kimura Disease: A chronic inflammatory disorder that can cause lymphadenopathy and eosinophilia, more common in Asian males, and might present with erythema if there's skin involvement.
  • Silicone Implant-Related Lymphadenopathy: In individuals with silicone breast implants, lymphadenopathy can occur due to a reaction to the silicone, potentially accompanied by erythema if there's an associated infection or inflammation.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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