Immediate Treatment for Hypoglycemia
The immediate treatment for hypoglycemia (blood glucose ≤70 mg/dL) is administration of 15-20 grams of oral glucose or carbohydrates for conscious patients, followed by blood glucose monitoring every 15 minutes until levels return to normal (>70 mg/dL). 1
Assessment and Initial Management
For Conscious Patients with Hypoglycemia:
- Confirm hypoglycemia with blood glucose measurement if possible (though treatment should not be delayed if testing is unavailable) 1
- Administer 15-20 grams of fast-acting carbohydrates:
- Pure glucose is preferred (glucose tablets)
- Alternatives: fruit juice, regular soda, honey, or other glucose-containing foods 1
- Recheck blood glucose after 15 minutes
- Repeat treatment if blood glucose remains <70 mg/dL
- Once blood glucose returns to normal (>70 mg/dL), provide a meal or snack if the next planned meal is more than 1 hour away 1
For Unconscious Patients or Those Unable to Take Oral Carbohydrates:
- Administer glucagon:
- Adults and children >25 kg or ≥6 years: 1 mg subcutaneously or intramuscularly
- Children <25 kg or <6 years: 0.5 mg subcutaneously or intramuscularly 2
- In medical settings: Administer 20-40 mL of 50% glucose solution intravenously 1
- Recheck blood glucose after 15 minutes
- If no response after 15 minutes, a second dose of glucagon may be administered while waiting for emergency assistance 2
Special Considerations
Severe Hypoglycemia
- Defined as hypoglycemia requiring assistance from another person for recovery 1
- May present with altered mental status, confusion, combativeness, seizures, or coma 1
- Requires immediate intervention to prevent serious complications or death
- After recovery, the patient should be evaluated for the cause of hypoglycemia and their diabetes management plan should be reassessed 1
Prevention of Recurrent Hypoglycemia
- After any episode of severe hypoglycemia, the diabetes treatment regimen should be reevaluated 1
- For patients with recurrent hypoglycemia, consider:
- Relaxing glycemic targets temporarily
- Adjusting medication dosing or timing
- Ensuring proper coordination between meals and medication 1
- Providing additional education on hypoglycemia recognition and management
Common Pitfalls to Avoid
- Delayed treatment: Hypoglycemia should be treated immediately upon recognition
- Inadequate follow-up: Failing to recheck blood glucose 15 minutes after initial treatment
- Overtreatment: Consuming excessive carbohydrates can lead to rebound hyperglycemia
- Failure to identify cause: Not investigating the underlying cause of hypoglycemia
- Neglecting prevention: Not making appropriate adjustments to prevent future episodes
For patients with diabetes, especially those on insulin or insulin secretagogues, carrying a source of fast-acting glucose at all times is essential for prompt self-treatment of hypoglycemia 1. Additionally, family members, caregivers, and close contacts should be educated on recognizing and treating hypoglycemia, including the use of glucagon for severe cases 1.