Can Apretude (cabotegravir) be stored in a refrigerator?

Storage Requirements for Apretude (Cabotegravir)

Apretude must be stored in a refrigerator at 2°C to 8°C (36°F to 46°F) and should not be frozen. 1

Storage Details and Handling

Apretude (cabotegravir) is an extended-release injectable HIV-1 antiretroviral medication used for pre-exposure prophylaxis (PrEP) in adults and adolescents weighing at least 35 kg who are at risk of sexually acquired HIV-1 infection 2. As a long-acting injectable medication, proper storage is critical to maintain its efficacy.

Specific Storage Requirements:

• Temperature range: 2°C to 8°C (36°F to 46°F)
• Do not freeze the medication
• Protect from light exposure
• Keep in original packaging until ready to use

Handling Considerations:

• Before administration, the medication should be allowed to come to room temperature
• Once at room temperature, the medication should be administered promptly
• Do not return to refrigeration after warming to room temperature

Importance of Cold Chain Maintenance

Maintaining the cold chain is essential for preserving the potency and effectiveness of temperature-sensitive medications like Apretude 3. The cold chain refers to the continuous refrigeration process that ensures medications remain within their required temperature range from manufacturer to administration.

Key Points for Healthcare Providers:

• Regular temperature monitoring of refrigerators is essential
• Refrigerators used for medication storage should be dedicated medical-grade units
• Temperature excursions should be documented and reported
• Medications should not be stored in refrigerator doors where temperature fluctuates most

Clinical Implications

Proper storage of Apretude is crucial for several reasons:

• Maintaining drug efficacy for HIV prevention
• Ensuring patient safety
• Preventing medication waste and associated costs
• Complying with manufacturer recommendations

Common Pitfalls to Avoid

1. Using household refrigerators: These often have inconsistent temperatures and frequent door openings that can compromise medication stability
2. Improper temperature monitoring: Failure to regularly check and document refrigerator temperatures
3. Freezing the medication: This can alter the molecular structure and reduce efficacy
4. Exposing to temperature fluctuations: Repeated warming and cooling cycles can degrade the medication
5. Storing near food items: This increases risk of contamination and temperature variations

For healthcare facilities administering Apretude, implementing proper storage protocols and staff education about medication storage requirements is essential to maintain the integrity of this important HIV prevention tool.