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Last updated: July 21, 2025View editorial policy

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Differential Diagnosis for Redness on Rectum

  • Single most likely diagnosis
    • Hemorrhoids: This is a common condition that can cause redness, itching, and discomfort in the rectal area due to swollen veins.
  • Other Likely diagnoses
    • Anal fissure: A small tear in the lining of the anus can cause pain, bleeding, and redness.
    • Proctitis: Inflammation of the rectum can be caused by infections, allergies, or irritation, leading to redness and discomfort.
    • Rectal prolapse: A condition where the rectum loses its normal attachments inside the body, allowing it to protrude out, which can cause redness and irritation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Rectal cancer: Although less common, rectal cancer can present with redness, bleeding, and changes in bowel habits, making it crucial not to miss this diagnosis.
    • Inflammatory bowel disease (IBD): Conditions like Crohn's disease and ulcerative colitis can cause severe inflammation and redness in the rectum and should not be overlooked.
    • Infectious proctitis: Certain infections, such as those caused by sexually transmitted diseases (e.g., gonorrhea, herpes), can lead to severe inflammation and require prompt treatment.
  • Rare diagnoses
    • Solitary rectal ulcer syndrome: A condition characterized by the presence of an ulcer in the rectum, which can cause redness, bleeding, and difficulty with bowel movements.
    • Lymphogranuloma venereum (LGV): A sexually transmitted infection that can cause proctitis, leading to redness, pain, and discharge.
    • Rectal vasculitis: Inflammation of the blood vessels in the rectum, which can be associated with systemic diseases and cause redness and bleeding.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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