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Last updated: July 23, 2025View editorial policy

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Differential Diagnosis for Unilateral Floaters

  • Single most likely diagnosis
    • Vitreous Detachment: This is the most common cause of unilateral floaters, often occurring as a result of age-related changes in the vitreous gel. It is usually benign but can be a precursor to more serious conditions.
  • Other Likely diagnoses
    • Retinal Tear or Detachment: These conditions can cause sudden onset of floaters, especially if they are unilateral. They are emergencies that require immediate medical attention to preserve vision.
    • Posterior Uveitis: Inflammation of the posterior segment of the eye can lead to floaters, among other symptoms like blurred vision and eye pain. It has various causes, including infections and autoimmune diseases.
    • Vitreous Hemorrhage: Bleeding into the vitreous gel can cause sudden vision changes, including floaters. It often results from diabetes, trauma, or retinal tears.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Retinal Malignancies: Although rare, tumors like retinoblastoma or choroidal melanoma can present with visual disturbances, including floaters. Early detection is crucial for treatment and prognosis.
    • Central Nervous System Lymphoma: This rare condition can cause ocular symptoms, including floaters, due to its potential to involve the eye. It requires prompt diagnosis and treatment.
  • Rare diagnoses
    • Ocular Toxoplasmosis: A parasitic infection that can reactivate in the eye, causing inflammation and symptoms like floaters, especially in immunocompromised individuals.
    • Sympathetic Ophthalmia: A rare, inflammatory condition that can occur after penetrating eye injury or surgery, leading to symptoms in the unaffected eye, including floaters.
    • Intraocular Foreign Body: Especially if the foreign body is located in the vitreous, it can cause floaters among other symptoms, depending on the material and location of the foreign body.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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