From the Research
Recommended Dosage of Prednisone
The recommended dosage of Prednisone for discharge in a patient with an allergic reaction in the emergency room (ER) is not explicitly stated in the provided studies. However, some studies provide information on the dosage of Prednisone used in similar situations:
- A study published in 1991 1 used a dosage of 40 mg per day, tapered to 0 mg per day over 8 days, to reduce the risk of relapse after treatment of acute asthma in the ER.
- A study published in 2010 2 used a dosage of 2 mg/kg/d (max 80 mg) in 2 divided doses for 5 days to treat moderate-to-severe acute chest syndrome of sickle cell disease.
- A study published in 1995 3 compared the outcomes of patients treated with a nontapering course of Prednisone to those treated with a typical tapering course, but does not specify the exact dosage used.
Considerations for Dosage
When determining the dosage of Prednisone, the following factors should be considered:
- The severity of the allergic reaction or condition being treated
- The patient's weight and age
- The potential for adverse effects, such as those reported in the study published in 1995 3, where 54% of patients reported adverse effects that could be attributed to Prednisone
- The need for alternative glucocorticoids in cases of adverse reaction to systemic glucocorticoids, as discussed in the study published in 2003 4