Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: July 29, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Pain with Intercourse

Single Most Likely Diagnosis

  • Vaginismus: This condition, characterized by involuntary muscle spasms in the vaginal wall, is a common cause of pain during intercourse, particularly in women who have not previously experienced pain-free intercourse.

Other Likely Diagnoses

  • Vulvodynia: A chronic condition that involves pain in the vulva, which can be exacerbated by intercourse, making it a likely cause of pain during sexual activity.
  • Endometriosis: A condition where tissue similar to the lining inside the uterus grows outside of it, leading to pain during intercourse due to the irritation and inflammation of the affected areas.
  • Vaginal Dryness: Often associated with menopause or other hormonal changes, vaginal dryness can cause discomfort or pain during intercourse.
  • Pelvic Inflammatory Disease (PID): An infection of the female reproductive organs that can cause pain during intercourse, along with other symptoms like abnormal vaginal discharge and fever.

Do Not Miss Diagnoses

  • Ovarian Cysts: While not all ovarian cysts cause pain during intercourse, large or ruptured cysts can lead to severe pain and are a condition that should not be missed due to potential complications.
  • Ectopic Pregnancy: Although less common, an ectopic pregnancy can cause pain during intercourse, among other symptoms, and is a medical emergency if not promptly diagnosed and treated.
  • Cancer of the Reproductive Organs: Cancers such as cervical, uterine, or ovarian cancer can cause pain during intercourse and, while less likely, are critical to diagnose early for effective treatment.

Rare Diagnoses

  • Lichen Sclerosus: A rare skin condition that can cause thinning and patchy skin in the genital area, leading to pain during intercourse.
  • Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome: A rare congenital disorder characterized by the underdevelopment or absence of the vagina and uterus, which can cause pain during attempted intercourse.
  • Pudendal Neuralgia: A condition involving pain from the pudendal nerve, which can be exacerbated by sitting or intercourse, though it's less commonly associated directly with pain during intercourse compared to other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.