From the Guidelines
GLP probiotics are not designed to mimic the function of GLP-1 medications, and their mechanisms and effects on the body are fundamentally different. The primary function of GLP-1 medications, such as those discussed in the context of managing type 2 diabetes 1, is to mimic the glucagon-like peptide-1 hormone, which plays a crucial role in regulating blood sugar levels and appetite by acting on specific receptors in the pancreas and brain. In contrast, GLP probiotics are dietary supplements that contain beneficial bacteria aimed at supporting gut health. These probiotics do not directly activate GLP-1 receptors or produce the same metabolic effects as GLP-1 medications.
Key differences between GLP-1 medications and GLP probiotics include:
- Mechanism of action: GLP-1 medications directly mimic the action of the glucagon-like peptide-1 hormone, while GLP probiotics work by supporting gut health through beneficial bacteria.
- Effects on blood sugar and weight: GLP-1 medications have been shown to effectively manage blood sugar levels and aid in weight loss, as discussed in guidelines for the management of type 2 diabetes 1. GLP probiotics, however, do not have sufficient scientific evidence to support claims of similar benefits.
- Regulation and prescription: GLP-1 medications are prescription drugs regulated by stringent clinical trials and guidelines, whereas GLP probiotics are dietary supplements with less regulatory oversight.
Given the lack of strong evidence supporting the use of GLP probiotics for metabolic or weight management benefits similar to those of GLP-1 medications, it is recommended to consult with a healthcare provider about prescription options rather than relying on probiotic supplements. This approach prioritizes evidence-based treatments that have been proven to reduce morbidity, mortality, and improve quality of life for individuals with type 2 diabetes or those seeking weight management solutions 1.
From the Research
GLP Probiotics and Their Function
- The provided studies do not directly address whether GLP probiotics are designed to mimic the function of GLP (Glucagon-like peptide) 2, 3, 4, 5, 6.
- However, the studies discuss the effects and mechanisms of GLP-1 receptor agonists, which are used to treat type 2 diabetes and obesity 2, 3, 4, 5, 6.
- GLP-1 receptor agonists stimulate insulin release, promote weight loss, and have various other effects on the body 2, 3, 4, 5, 6.
- There is no direct evidence in the provided studies to suggest that GLP probiotics are designed to mimic these functions.
GLP-1 Receptor Agonists
- GLP-1 receptor agonists have been shown to be effective in reducing HbA1c levels, fasting plasma glucose levels, and body weight in patients with type 2 diabetes 2, 5.
- They also have various other effects, including reducing the risk of kidney outcomes and cardiovascular events 4, 5.
- However, they can also have adverse effects, such as nausea, gastrointestinal disorders, and hypoglycemia 2, 3, 4, 6.