From the Research
Glutathione plays a crucial role in protecting against oxidative stress caused by high-altitude exposure, and its supplementation may help alleviate symptoms of Acute Mountain Sickness (AMS) by neutralizing reactive oxygen species and supporting cellular respiration. When ascending to higher elevations, the body experiences increased production of reactive oxygen species (ROS) and free radicals due to hypoxic conditions. Glutathione works by neutralizing these harmful compounds, protecting cells from oxidative damage, and supporting cellular respiration 1. It also helps maintain the integrity of red blood cells, potentially improving oxygen delivery to tissues. Additionally, glutathione supports the detoxification of harmful substances in the body and may reduce inflammation associated with altitude exposure.
The mechanism of action of glutathione on AMS is closely related to its antioxidant properties, which help mitigate the effects of oxidative stress on the body. At high altitudes, the body's natural antioxidant defenses are overwhelmed by the increased production of ROS, leading to cellular damage and inflammation 2. Glutathione supplementation can help bolster the body's antioxidant defenses, reducing the severity of AMS symptoms. While the exact dosage and duration of glutathione supplementation for AMS prevention or treatment are not well established, available evidence suggests that supplementation may be beneficial in reducing oxidative stress and alleviating symptoms 1.
It is essential to note that established medications like acetazolamide (125-250mg twice daily) remain the standard preventive treatment for altitude sickness, and glutathione supplementation should not be relied upon as the sole means of prevention or treatment 3, 4, 5. If considering glutathione supplementation for altitude sickness, it's advisable to start taking it several days before ascent and continue throughout the stay at high altitude, though consulting with a healthcare provider before use is recommended, especially for those with pre-existing conditions.
Key points to consider:
- Glutathione supplementation may help alleviate symptoms of AMS by reducing oxidative stress and supporting cellular respiration
- The exact dosage and duration of glutathione supplementation for AMS prevention or treatment are not well established
- Established medications like acetazolamide remain the standard preventive treatment for altitude sickness
- Glutathione supplementation should not be relied upon as the sole means of prevention or treatment
- Consulting with a healthcare provider before use is recommended, especially for those with pre-existing conditions.