From the Research
Glutathione plays a crucial role in protecting against reactive oxygen species and oxidative stress induced damages at high altitudes, potentially reducing the risk of Acute Mountain Sickness (AMS) by neutralizing harmful compounds and maintaining proper mitochondrial function. When ascending to higher elevations, the body experiences increased production of reactive oxygen species (ROS) and free radicals due to hypoxic conditions, which can damage cells and tissues. Glutathione works by neutralizing these harmful compounds, potentially reducing inflammation and protecting cells from oxidative damage. Additionally, glutathione helps maintain proper mitochondrial function during hypoxic stress, supporting energy production when oxygen is limited. It may also help regulate nitric oxide, improving blood flow and oxygen delivery to tissues.
Key Points
- Glutathione metabolism is affected by high-altitude exposure, with significant decreases in reduced glutathione and increases in oxidized glutathione levels 1
- Antioxidant supplementation, such as N-acetyl cysteine (NAC) and vitamin E, can ameliorate the adverse effects of high-altitude exposure on glutathione metabolism and antioxidant defense mechanisms 1
- While glutathione supplements are available (typically 250-500mg daily), there is currently limited clinical evidence specifically supporting glutathione supplementation for altitude sickness prevention or treatment
- Established medications like acetazolamide (Diamox, 125-250mg twice daily) remain the standard preventive treatment for altitude sickness, with doses of 500-750mg/day showing enhanced effectiveness in minimizing symptoms of AMS 2
- If considering glutathione for altitude sickness, it's best used as a complementary approach alongside proper acclimatization, hydration, and conventional medications when necessary.