Active Ingredient of Psyllium Husk
The active ingredient of psyllium husk is psyllium husk itself, which contains approximately 3.4 g of psyllium husk per 5.8 g packet. 1
Composition and Mechanism
Psyllium husk is derived from the outer seed coat of Plantago ovata and contains:
- Soluble and insoluble fiber in a ratio of approximately 7:3 2
- Highly branched, gel-forming arabinoxylan as its primary component 3
- No other active pharmaceutical ingredients - the natural fiber itself is the therapeutic agent
Therapeutic Properties
Psyllium husk works through several mechanisms:
- Forms a viscous gel in the intestinal tract when mixed with water
- Increases stool weight and water content
- Reduces transit time through the colon
- Has prebiotic potential that may stimulate beneficial gut bacteria 4
Clinical Applications
Psyllium husk is clinically proven effective for:
Constipation management:
Irritable Bowel Syndrome (IBS):
Dosing Considerations
- Standard dosage: 6.8-10.8g daily, with an optimal dose of 20g daily for constipation relief 5
- Should be taken with 8-10 ounces of fluid immediately before meals 5
- FDA-approved products typically contain approximately 3.4g of psyllium husk per 5.8g packet 1
Important Clinical Notes
- Unlike many medications, psyllium husk does not have a separate "active ingredient" - the fiber itself provides the therapeutic effect
- Psyllium husk is considered safe during pregnancy due to lack of systemic absorption 5
- Primary side effect is flatulence, with other potential side effects including bloating and abdominal discomfort 5
- Not recommended for opioid-induced constipation, where stimulant laxatives are preferred 5
Psyllium husk's therapeutic effects come from the natural plant fiber itself rather than from an isolated chemical compound, making it distinct from conventional pharmaceutical products that contain specific active pharmaceutical ingredients.