Initial Management of Epistaxis
The first-line treatment for a patient presenting with epistaxis is firm sustained compression to the lower third of the nose for at least 5 minutes, with the patient sitting upright and the head tilted slightly forward. 1, 2
Assessment and Initial Management
Immediate Actions
Position the patient properly:
- Have the patient sit upright with head tilted slightly forward
- This position prevents blood from flowing down the throat
Apply direct pressure:
- Compress the lower third (soft portion) of the nose firmly
- Maintain compression for at least 5-15 minutes continuously
- This allows time for clot formation and stabilization
Apply vasoconstrictor (if available):
- Oxymetazoline or phenylephrine nasal spray
- Success rate of 65-75% when combined with compression 3
- Apply to the bleeding site after blowing nose to clear clots
Identifying Patients Requiring Prompt Management
Assess for signs requiring urgent intervention 1, 2:
- Bleeding duration >30 minutes
- History of hospitalization for nosebleeds
- Prior blood transfusion for epistaxis
- More than 3 recent episodes
- Bilateral bleeding
- Blood flowing from mouth
- Tachycardia, syncope, or orthostatic hypotension
- Patients on anticoagulation/antiplatelet medications
Next Steps After Initial Compression
If bleeding persists after initial compression:
Identify bleeding site 1:
- Perform anterior rhinoscopy after removing blood clots
- Determine if bleeding is anterior (90-95% of cases) or posterior (5-10%)
For visible bleeding site 1, 2:
- Apply topical anesthetic (lidocaine or tetracaine)
- Perform cauterization (chemical or electrical) only to the active bleeding site
- Electrocautery is more effective than chemical cautery (14.5% vs. 35.1% recurrence) 3
If bleeding site cannot be identified 1:
- Proceed to nasal packing
- Use resorbable packing for patients with suspected bleeding disorders or those on anticoagulation/antiplatelet medications
Nasal Packing Considerations
When applying nasal packing 1:
- Ensure proper placement to apply pressure to the bleeding site
- For patients on anticoagulants, use resorbable materials to reduce risk of rebleeding during removal
- Educate patient about type of packing, removal timing, and signs requiring reassessment
Special Considerations
Patients on anticoagulation/antiplatelet medications 1, 2:
- Do not discontinue medications without consulting the prescribing physician
- In absence of life-threatening bleeding, use standard first-line treatments before considering medication changes
- Consider topical tranexamic acid as an adjunct treatment (reduces rebleeding risk from 67% to 47%) 4
- Consider nasal endoscopy to identify bleeding sites (87-93% success rate)
- Assess for nasal telangiectasias in patients with recurrent bilateral nosebleeds
Prevention Education
Educate patients about preventive measures 1, 2:
- Avoid digital trauma (nose picking) and vigorous nose blowing
- Apply moisturizing agents to the anterior nasal septum
- Use humidification at bedside
- Regular use of saline nasal sprays to keep nasal mucosa moist
Common Pitfalls to Avoid
- Insufficient compression time (less than 5 minutes)
- Bilateral septal cautery (increases risk of septal perforation)
- Premature discontinuation of anticoagulants without consulting prescribing physician
- Failure to recognize posterior epistaxis, which is more serious and often requires hospitalization
When to Refer
Consider referral to otolaryngology or emergency department for 1, 2:
- Posterior epistaxis
- Bleeding not controlled with anterior packing
- Recurrent epistaxis despite treatment
- Suspected underlying pathology requiring endoscopic evaluation
Recent evidence suggests that topical tranexamic acid may be more effective than traditional nasal packing, with faster bleeding control (within 10 minutes) and fewer rebleeding episodes 5. A dose of 1000 mg appears to be more effective than 500 mg 6.