From the Research
Bone Marrow Inflammation and Cystitis Activity
- Bone marrow inflammation can lead to various complications, including cystitis, particularly in patients undergoing bone marrow transplantation 1, 2, 3, 4.
- Hemorrhagic cystitis is a well-documented adverse event experienced by patients undergoing hematopoietic stem cell transplantation, with a reported incidence of 13-38% 2.
- The development of hemorrhagic cystitis after bone marrow transplantation is associated with several risk factors, including the use of certain conditioning regimens, allogeneic transplantation, and acute graft-versus-host disease (GVHD) 2, 3, 4.
Risk Factors for Cystitis
- Male sex and receipt of T cell-depleted grafts or grafts from unrelated donors are significant risk factors for severe hemorrhagic cystitis 3.
- The use of busulphan during conditioning and acute GVHD are also significant risk factors for clinically overt hemorrhagic cystitis 4.
- Polyoma BK viruria has been detected in patients with hemorrhagic cystitis, suggesting a possible role in the pathogenesis of the disease 2, 4.
Bone Marrow Activation and Inflammation
- Bone marrow activation is associated with metabolic syndrome and early atherosclerosis, and is characterized by increased hematopoiesis and systemic inflammation 5.
- The association between bone marrow activation and metabolic syndrome is maintained even in the absence of systemic inflammation, suggesting a possible link between bone marrow inflammation and cystitis activity 5.