From the Research
Interleukin-18 (IL-18) and Cystatin C Relationship
- The relationship between IL-18 and Cystatin C levels has been studied in various contexts, including diabetic nephropathy, acute kidney injury, and critically ill patients 1, 2, 3, 4, 5.
- In diabetic nephropathy, IL-18 has been found to contribute to the progression of the disease, and Cystatin C levels have been observed to increase in severe microangiopathy groups 1.
- In acute kidney injury, both IL-18 and Cystatin C have been identified as potential biomarkers, with elevated levels associated with AKI development and poor renal function 2, 3.
- The impact of sepsis on urinary IL-18 and Cystatin C levels has also been investigated, with results suggesting that sepsis can influence the diagnostic value of IL-18 in detecting AKI 4.
- In critically ill patients with AKI, serum IL-18 has been found to predict short-term prognosis, with higher levels associated with increased hospital mortality 5.
IL-18 Effects on Cystatin C Levels
- While the exact mechanism of IL-18's effect on Cystatin C levels is not fully understood, studies suggest that IL-18 may contribute to the progression of kidney disease and influence Cystatin C levels indirectly 1, 2, 3.
- Elevated IL-18 levels have been associated with increased Cystatin C levels in various studies, suggesting a potential link between the two biomarkers 1, 2, 3.
- However, the relationship between IL-18 and Cystatin C is complex and may be influenced by various factors, including the underlying disease condition and the presence of sepsis or other complications 4, 5.