Managing Adderall (Amphetamine) Withdrawal
Withdrawal from amphetamines like Adderall should be managed in a supportive environment with symptomatic treatment, as no specific medication is recommended for amphetamine withdrawal. 1
Assessment and Recognition of Withdrawal Symptoms
- Common withdrawal symptoms include:
- Drug craving
- Anxiety and agitation
- Insomnia
- Abdominal pain
- Vomiting and diarrhea
- Diaphoresis (excessive sweating)
- Mydriasis (pupil dilation)
- Tremor
- Tachycardia
Recommended Management Approach
1. Supportive Environment
- Withdrawal is best undertaken in a supportive environment 1
- Consider involving family members in the treatment process
- Encourage engagement with mutual help groups when appropriate
2. Symptomatic Medication Management
- No specific medication is recommended for amphetamine withdrawal 1
- Relief of symptoms can be achieved with targeted symptomatic medications:
- For agitation/anxiety: Short-term benzodiazepines
- For sleep disturbance: Sleep aids
- For nausea/vomiting: Antiemetics
3. Monitoring for Complications
- Monitor closely for less common but serious complications:
- Depression during withdrawal
- Psychosis during withdrawal
- In these cases, seek specialist advice 1
4. Psychosocial Support
- Offer short duration psychosocial support modeled on motivational principles 1
- For individuals who don't respond to brief interventions, consider referral for specialist assessment
Special Considerations
- Tapering approach: While no specific tapering protocol is recommended for amphetamines, gradual reduction is generally preferred over abrupt discontinuation to minimize withdrawal symptoms
- Monitoring frequency: Schedule frequent follow-ups during the withdrawal process
- Duration of support: Continue monitoring and support for several weeks as withdrawal symptoms may persist
When to Refer to Specialist Care
- When withdrawal symptoms are severe or prolonged
- If depression or psychosis develops during withdrawal
- For patients with comorbid substance use disorders
- When patients don't respond to brief psychosocial interventions 1
The World Health Organization guidelines specifically state that withdrawal from amphetamines is best managed with supportive care and symptomatic treatment rather than replacement therapy, unlike opioid withdrawal which has specific medication protocols 1.