What is the recommended treatment for canker sores in infants?

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Last updated: August 9, 2025View editorial policy

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Treatment of Canker Sores in Infants

For infants with canker sores, topical 2.5% lidocaine ointment should be applied cautiously to the affected area for pain relief, along with barrier protection using white soft paraffin ointment applied every 2-4 hours throughout the healing process. 1

First-Line Treatment Approach

Pain Management

  • Apply topical 2.5% lidocaine ointment cautiously to the affected area 1
    • Use sparingly and only when necessary for pain relief
    • For children under 12 years, consult a doctor before application 2
    • Do not apply more than 3-4 times daily 2
    • Wash hands with soap and water after application 2

Barrier Protection

  • Apply white soft paraffin ointment (petroleum jelly) to the affected area 1
    • Apply immediately after diagnosis and then every 2-4 hours
    • Creates a protective barrier over the ulcer
    • Promotes healing and reduces discomfort

Supportive Care Measures

Oral Hygiene

  • Gently clean the mouth with warm saline solution using a soft cloth or gauze 1
  • Avoid alcohol-based mouth rinses as they can cause further irritation 1
  • Maintain adequate hydration to keep the mouth moist 1

Dietary Modifications

  • Offer soft, moist, non-irritating foods 1
  • Avoid acidic, spicy, salty, or rough/coarse foods that may irritate the ulcer 1
  • Ensure adequate fluid intake to prevent dehydration 1

Monitoring and Follow-up

  • Monitor oral intake to prevent dehydration 1
  • Follow up within 3-5 days if symptoms are not improving 1
  • Assess for signs of secondary infection:
    • Increased redness
    • Swelling
    • Fever
    • Difficulty feeding or drinking

Special Considerations for Infants

  • Infants have more sensitive oral mucosa and are at higher risk for systemic absorption of topical medications
  • Use minimal amounts of topical anesthetics to avoid potential toxicity
  • Monitor for signs of difficulty feeding or dehydration
  • Consider timing application of pain relief before feeding to improve oral intake

When to Seek Additional Medical Care

  • If the infant refuses to eat or drink
  • If ulcers persist beyond 2 weeks
  • If ulcers are numerous or unusually large
  • If the infant develops fever or appears ill
  • If there are signs of dehydration (decreased urination, dry mouth, lethargy)

Common Pitfalls and Caveats

  • Avoid using adult-strength over-the-counter canker sore medications in infants without medical supervision
  • Do not use topical corticosteroids in infants without specific medical direction
  • Avoid tetracycline-based medications in children under 8 years of age due to risk of teeth staining 3
  • Be cautious with antiseptic mouthwashes in infants as they may swallow the solution
  • Remember that recurrent canker sores may indicate an underlying condition requiring further evaluation

Canker sores (aphthous ulcers) typically resolve spontaneously within 7-14 days. The treatment approach focuses on pain management and supporting the natural healing process while preventing complications in this vulnerable population.

References

Guideline

Lip and Mouth Disorders Treatment Guideline

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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