From the FDA Drug Label
Apixaban tablets can cause a skin rash or severe allergic reaction. Call your doctor or get medical help right away if you have any of the following symptoms: • chest pain or tightness • swelling of your face or tongue • trouble breathing or wheezing • feeling dizzy or faint
The symptoms of an allergic reaction to apixaban include swelling of your face or tongue, but it does not specifically mention neck swelling. However, given the possibility of swelling of your face or tongue, it is possible that an allergic reaction could cause swelling in other areas, including the neck. 1
From the Research
Allergic Reactions to Eliquis (Apixaban)
- There is no direct evidence in the provided studies that an allergic reaction to Eliquis (apixaban) can cause neck swelling specifically 2, 3, 4, 5, 6.
- However, the studies suggest that apixaban can cause various hypersensitivity reactions, including dermatological reactions such as rash and urticaria 3, 4.
- Angioedema, a condition characterized by deep dermal, subcutaneous, and/or submucosal swelling, can be caused by allergic reactions, including those to medications 2, 6.
- While the studies do not specifically mention neck swelling as a side effect of apixaban, they do highlight the importance of monitoring for and managing hypersensitivity reactions, including angioedema, in patients taking the medication 2, 3, 4, 6.
- The pathophysiology of angioedema can involve elevated bradykinin levels, and standard antiallergic drugs such as glucocorticoids and antihistamines may be ineffective in nonallergic angioedema forms 2, 6.