From the Research
Flaxseed has been shown to lower Lipoprotein(a) (Lp(a)) levels, with a significant decrease in plasma Lp(a) levels observed in a meta-analysis of randomized controlled trials. The most recent and highest quality study, a 2021 meta-analysis 1, found a significant decrease in plasma Lp(a) levels, with a standardized mean difference of -0.22,95% confidence interval: -0.41 to -0.04, P = .017, following supplementation with flaxseed-containing products.
Some key points to consider when using flaxseed to lower Lp(a) levels include:
- Consuming 30-50 grams of ground flaxseed daily for at least 12 weeks may reduce Lp(a) by approximately 14-17% in some individuals 2, 1
- Using freshly ground flaxseed rather than flaxseed oil may be more effective, as the fiber components appear important for any potential Lp(a)-lowering effect 2, 3
- Incorporating ground flaxseed into foods like yogurt, oatmeal, or smoothies, and storing it in the refrigerator to prevent rancidity, may be a convenient and effective way to consume flaxseed 2
- The mechanism may involve the high content of alpha-linolenic acid (an omega-3 fatty acid), lignans, and soluble fiber in flaxseed, which could affect lipoprotein metabolism 2, 3
However, it is essential to note that flaxseed should not replace conventional medical treatments for cardiovascular risk management, and individuals with high Lp(a) levels should discuss comprehensive management strategies with their healthcare provider, as Lp(a) is largely genetically determined and difficult to modify significantly through lifestyle interventions alone 4, 5.