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Last updated: August 11, 2025View editorial policy

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Differential Diagnosis for Labia Irritation

  • Single most likely diagnosis
    • Contact dermatitis: This is often the most common cause of labia irritation due to exposure to irritants such as soaps, dyes in toilet paper, or certain fabrics. The symptoms can include redness, itching, and burning sensations.
  • Other Likely diagnoses
    • Yeast infections (candidiasis): Caused by an overgrowth of Candida fungus, leading to itching, redness, and a white discharge.
    • Bacterial vaginosis: An imbalance of naturally occurring bacteria in the vagina, leading to symptoms like unusual discharge, odor, and sometimes irritation.
    • Physiological discharge: Normal vaginal discharge can sometimes cause irritation, especially if it's more abundant than usual or if the individual has sensitive skin.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Herpes simplex virus (HSV): Although less common, HSV can cause significant irritation, along with vesicles or ulcers, and can have serious implications if not treated properly.
    • Syphilis: A sexually transmitted infection that can cause ulcers or sores, which might be mistaken for irritation. It's crucial to diagnose and treat syphilis early to prevent long-term complications.
    • Lichen sclerosis: A rare condition that causes thinning and patchy skin which is very sensitive and can tear easily, leading to significant discomfort and potential for scarring if not managed.
  • Rare diagnoses
    • Lichen planus: An inflammatory condition that can affect the mucous membranes, including the vulva, causing irritation and sometimes painful sores.
    • Vulvar intraepithelial neoplasia (VIN): Abnormal cell growth that can cause irritation and is a precursor to vulvar cancer. Early detection is crucial for effective treatment.
    • Foreign body reaction: Though rare, the presence of a foreign object in the vagina can cause irritation and other symptoms, and its removal is necessary to alleviate the condition.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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