What is the best treatment for a wasp sting?

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Last updated: August 12, 2025View editorial policy

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Best Treatment for a Wasp Sting

The best treatment for a wasp sting includes thorough cleaning with soap and water, applying a medium-potency topical corticosteroid 2-3 times daily, and using oral antihistamines for itch relief. 1

Immediate Management

  1. Clean the wound thoroughly with soap and water to remove potential contaminants 1
  2. Apply a medium-potency topical corticosteroid 2-3 times daily to reduce inflammation 1
  3. Use oral antihistamines for itch relief:
    • Non-sedating options (daytime): cetirizine or loratadine
    • Sedating options (nighttime): diphenhydramine 1
  4. For pain relief:
    • Apply topical lidocaine if skin is intact
    • Take over-the-counter acetaminophen or NSAIDs 1
  5. Apply cold compresses (never apply ice directly to skin) 1

Monitoring and Warning Signs

Monitor the sting site for 48-72 hours for signs of infection or progression 1. Seek immediate medical attention if you develop:

  • Signs of anaphylaxis: flushing, apprehension, syncope, tachycardia, hypotension, convulsions, vomiting, diarrhea, abdominal cramps, airway swelling, laryngospasm, bronchospasm, pruritus, urticaria, angioedema, or swelling of eyelids, lips, and tongue 2
  • Signs of infection: persistent redness, warmth, swelling, or tenderness at the sting site 2
  • Increasing redness, warmth, swelling, purulent discharge, worsening pain, fever, or systemic symptoms 1

Special Considerations

Anaphylaxis Management

If signs of anaphylaxis develop, emergency treatment with injectable epinephrine is recommended:

  • Adult dosage: 0.3-0.5 mg intramuscularly into anterolateral thigh
  • Children ≥30 kg: 0.3-0.5 mL intramuscularly into anterolateral thigh 1, 2

Delay in epinephrine administration has been associated with fatal sting reactions, emphasizing the importance of prompt treatment 1.

Prevention of Future Stings

  • Avoid wearing brightly colored clothing or flowery prints
  • Avoid using strongly scented materials that might attract insects
  • Wear long pants, long-sleeved shirts, socks, and shoes when outdoors
  • Avoid walking barefoot or with open shoes
  • Remove known nests in the vicinity of home (by trained professionals)
  • Avoid areas with high uncut grass, weeds, and low brush
  • Be cautious near bushes, eaves, and attics 1

Follow-up Care

  • Follow up within 24 hours either by phone or office visit 1
  • Patients with a history of systemic reactions to insect stings should be referred to an allergist for evaluation for venom immunotherapy and should carry injectable epinephrine 1

Important Caveats

  • Unlike bees, wasps can sting multiple times as they do not lose their stinger 3
  • Antibiotics are not routinely needed for early, uninfected insect stings but may be considered if signs of infection develop 1
  • Rare complications of wasp stings include skin and soft tissue necrosis 4 and rhabdomyolysis (especially with multiple stings) 5
  • Do not pluck or squeeze the stinger if present (more common with bee stings than wasp stings), as this may inject more venom into the wounded site 6

References

Guideline

Management of Bite Wounds

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Hymenoptera stings.

Clinical techniques in small animal practice, 2006

Research

Skin and soft tissue necrosis following hymenoptera sting.

Journal of cutaneous medicine and surgery, 2003

Research

Rhabdomyolysis due to Multiple Wasp Stings.

Case reports in dermatological medicine, 2012

Research

Bee or Wasp Sting.

Wounds : a compendium of clinical research and practice, 2017

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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