What are closed comedones (whiteheads)?

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Last updated: March 7, 2025View editorial policy

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From the Research

Closed comedones, also known as whiteheads, are a type of non-inflammatory acne lesion that occurs when hair follicles become clogged with oil, dead skin cells, and bacteria, resulting in a closed pore that prevents oxygen from reaching the clogged material. They are characterized by small, white or flesh-colored bumps on the skin, commonly appearing on the face, particularly on the nose, chin, and forehead, but can also develop on the chest, back, and shoulders 1. According to the most recent and highest quality study, the treatment of closed comedones involves the use of gentle cleansers containing salicylic acid (2%) or benzoyl peroxide (2.5-5%) once or twice daily, as well as over-the-counter retinoids like adapalene 0.1% gel applied nightly to help unclog pores and promote cell turnover 1. Some key points to consider when treating closed comedones include:

  • Avoiding picking or squeezing whiteheads, as this can lead to inflammation, scarring, and spreading of bacteria
  • Using non-comedogenic skincare products and makeup to prevent further pore blockage
  • Maintaining a consistent skincare routine to manage this common skin condition effectively
  • Considering prescription treatments such as stronger retinoids, topical antibiotics, or oral medications for persistent cases 2, 3, 4, 5. It's worth noting that acne, including closed comedones, is now considered an inflammatory disease even before the onset of clinical lesions, which highlights the importance of early and effective treatment to prevent long-term consequences 5.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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