From the FDA Drug Label
Ciprofloxacin has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections... Aerobic gram-positive microorganisms Staphylococcus saprophyticus
The treatment for Staphylococcus saprophyticus infection is ciprofloxacin 1.
From the Research
Staphylococcus saprophyticus infections are typically treated with a 3-7 day course of oral antibiotics, with first-line treatment options including trimethoprim-sulfamethoxazole (TMP-SMX), nitrofurantoin, or cephalexin, as supported by the most recent study 2. The choice of antibiotic should be guided by local resistance patterns and patient-specific factors.
- TMP-SMX is a commonly used first-line treatment, with a dose of 160/800 mg twice daily 2.
- Nitrofurantoin is another option, with a dose of 100 mg four times daily, although its use may be limited by resistance concerns 2.
- Cephalexin is also a viable option, with a dose of 500 mg four times daily, although its effectiveness against S. saprophyticus may vary 3. Fluoroquinolones like ciprofloxacin can be used as alternatives, but are generally reserved for more complicated cases due to resistance concerns 4. It is essential to note that S. saprophyticus is naturally resistant to nalidixic acid, but typically remains susceptible to most other antibiotics used for UTIs 2. Adequate hydration is also crucial during treatment to help flush bacteria from the urinary tract. If symptoms persist after treatment, urine culture with susceptibility testing should be performed to guide further antibiotic selection 5. In cases of methicillin-resistant S. saprophyticus, alternative treatments like daptomycin may be considered, as shown in a recent case report 6.