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Last updated: August 14, 2025View editorial policy

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Differential Diagnosis for Chest Asymmetry

Single Most Likely Diagnosis

  • Pectus excavatum or Pectus carinatum: These are congenital conditions that affect the shape of the chest wall, leading to asymmetry. Pectus excavatum is a sunken chest, while pectus carinatum is a protruding chest. They are relatively common and can be diagnosed based on physical examination and imaging studies.

Other Likely Diagnoses

  • Scoliosis: A condition characterized by an abnormal lateral curvature of the spine, which can cause chest asymmetry due to the rotation and deformity of the thoracic cage.
  • Muscular atrophy or hypertrophy: Asymmetrical development or atrophy of the chest muscles (e.g., pectoralis major) can lead to noticeable chest asymmetry.
  • Previous thoracic surgery or trauma: Scarring or deformity from previous surgeries or injuries to the chest wall can result in asymmetry.

Do Not Miss Diagnoses

  • Lung cancer or metastasis: Although less common, a new onset of chest asymmetry could be a sign of a underlying malignancy, such as lung cancer, which can cause asymmetrical growth or destruction of lung tissue.
  • Pneumothorax: A collapsed lung can lead to chest asymmetry due to the difference in lung volume between the two sides. This is a medical emergency requiring prompt diagnosis and treatment.
  • Thoracic aortic aneurysm or dissection: These are life-threatening conditions that can cause chest asymmetry among other symptoms. Early diagnosis is crucial for survival.

Rare Diagnoses

  • Poland syndrome: A rare congenital condition characterized by underdevelopment or absence of the pectoralis major muscle on one side of the body, leading to noticeable chest asymmetry.
  • Jeune syndrome: A rare genetic disorder that affects the development of the bones, including those in the chest, leading to asymmetry and other skeletal abnormalities.
  • Asymmetric chest wall deformities due to neurofibromatosis: In some cases, neurofibromatosis type 1 can cause asymmetric growth of the chest wall due to the presence of neurofibromas.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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