From the Research
Entresto (sacubitril/valsartan) does have a diuretic effect due to its valsartan component, which is an angiotensin II receptor blocker (ARB) that can increase urine production by reducing sodium reabsorption in the kidneys. This diuretic effect is not as potent as traditional diuretics like loop or thiazide diuretics, but it can still contribute to the medication's benefits in reducing blood pressure and fluid retention in patients with heart failure 1. The sacubitril component of Entresto, a neprilysin inhibitor, also has a natriuretic effect, which can enhance the diuretic effect of valsartan. Patients taking Entresto may experience increased urination, especially during the initial weeks of treatment. This diuretic effect means patients should be monitored for dehydration, especially elderly patients or those taking other diuretics. Adequate fluid intake is recommended while taking this medication to prevent dehydration.
Some key points to consider when using Entresto:
- The diuretic effect of Entresto can be beneficial in reducing fluid retention and blood pressure in patients with heart failure.
- Patients should be monitored for signs of dehydration, such as dizziness, lightheadedness, and decreased urine output.
- Adequate fluid intake is essential to prevent dehydration, especially in elderly patients or those taking other diuretics.
- The sacubitril component of Entresto can enhance the diuretic effect of valsartan, leading to increased urine production.
It's worth noting that the provided evidence does not directly address the diuretic effect of Entresto, but rather discusses the mechanisms of action of different diuretic classes and their effects on cardiovascular outcomes 2, 3, 4, 1, 5. However, based on the known mechanisms of action of sacubitril and valsartan, it is reasonable to conclude that Entresto has a diuretic effect.