Can Nexplanon (etonogestrel) cause syncope (fainting)?

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From the Research

Yes, Nexplanon (etonogestrel implant) can potentially cause syncope (fainting) in some individuals, though it is not among the most common side effects. Syncope with Nexplanon may occur due to vasovagal reactions during insertion or removal procedures, or as a rare side effect related to hormonal changes. The progestin hormone in Nexplanon can affect blood pressure and cardiovascular function in some users. If you experience fainting or pre-syncope symptoms (lightheadedness, dizziness, blurred vision) while using Nexplanon, you should contact your healthcare provider promptly. These symptoms could also be related to other causes and should not be ignored. Your provider might recommend position changes when standing up (rising slowly), adequate hydration, and possibly reconsidering your contraceptive method if syncope becomes recurrent or concerning. The risk of syncope is generally highest during the insertion procedure itself rather than as an ongoing side effect during the three years the implant remains effective, as noted in various studies 1, 2, 3, 4. Additionally, managing vasovagal syncope, which could be a contributing factor, involves adequate hydration, increased salt intake, and careful withdrawal of certain medications, as well as considering treatments like fludrocortisone and midodrine if syncope recurrences are a problem 5. It's crucial to approach each case individually, considering the patient's overall health and the specific circumstances of their syncope or pre-syncope episodes. Key points to consider include:

  • The potential for vasovagal reactions during insertion or removal
  • The impact of hormonal changes on blood pressure and cardiovascular function
  • The importance of prompt medical evaluation for syncope or pre-syncope symptoms
  • The consideration of alternative treatments or adjustments to the contraceptive method if syncope becomes a recurring issue.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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