From the Research
The histopathology findings in lipodermatosclerosis include dermal edema, fibrosis, and inflammation, with the most recent and highest quality study 1 providing the most relevant information on this condition. The histopathology of lipodermatosclerosis is characterized by:
- Dermal edema, which can be visualized by high-frequency ultrasonography 2
- Fibrosis and inflammation of the skin and subcutaneous tissues
- Hyperpigmentation and atrophie blanche
- Induration and hardening of the subcutaneous tissue The physical examination should focus on the affected areas, typically the medial lower legs, describing the characteristic "inverted champagne bottle" appearance with reddish-brown discoloration, induration, and fibrosis of the skin. Some key points to note in the histopathology of lipodermatosclerosis include:
- The presence of dermal edema, which is a key feature of the condition 2
- The characteristic "inverted champagne bottle" appearance of the affected leg 1
- The presence of hyperpigmentation, atrophie blanche, and induration of the skin 3
- The hardening of the subcutaneous tissue, which can be palpated on examination 4 It is essential to document these findings thoroughly, as they provide a baseline for monitoring disease progression and treatment response for this chronic inflammatory condition of the skin and subcutaneous tissues resulting from venous hypertension 5.