What are the causes of a sore throat and chills?

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Last updated: March 9, 2025View editorial policy

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Differential Diagnosis for Sore Throat and Chills

  • Single Most Likely Diagnosis
    • Viral Pharyngitis: This is the most common cause of sore throat and is often accompanied by chills, especially during the initial stages of the illness. The justification for this diagnosis is based on the high prevalence of viral infections in the community and the typical presentation of sore throat and chills.
  • Other Likely Diagnoses
    • Bacterial Pharyngitis (Strep Throat): Caused by Group A beta-hemolytic streptococcus, this condition presents with sore throat, chills, and fever. The presence of a sore throat and chills, along with other symptoms like swollen lymph nodes, makes this a likely diagnosis.
    • Influenza: Influenza can cause sore throat, chills, fever, and body aches, making it another likely diagnosis, especially during flu season.
    • Mononucleosis: Caused by the Epstein-Barr virus, this condition can present with sore throat, chills, fever, and fatigue, particularly in young adults.
  • Do Not Miss Diagnoses
    • Epiglottitis: Although rare, epiglottitis is a life-threatening condition that requires immediate attention. It can present with sore throat, chills, difficulty swallowing, and shortness of breath.
    • Lemierre's Syndrome: A rare but serious condition characterized by a sore throat followed by neck pain, chills, and fever, which can progress to sepsis if not treated promptly.
    • Peritonsillar Abscess: A complication of bacterial pharyngitis, this condition can cause severe sore throat, chills, fever, and difficulty swallowing, and requires urgent medical attention.
  • Rare Diagnoses
    • Diphtheria: A rare bacterial infection that can cause sore throat, chills, and a distinctive membrane covering the tonsils and throat.
    • Tuberculosis: Although rare in some parts of the world, tuberculosis can cause chronic sore throat, chills, and other systemic symptoms, particularly in immunocompromised individuals.
    • HIV Infection: Acute HIV infection can present with sore throat, chills, fever, and rash, among other symptoms, making it a rare but important consideration in the differential diagnosis.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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