Treatment for Photokeratitis/Photoconjunctivitis
The primary treatment for photoconjunctivitis (UV-induced conjunctivitis) involves immediate removal from UV exposure, cool compresses, preservative-free lubricating eye drops, and pain management, with most cases resolving within 24-48 hours without permanent damage. 1
Pathophysiology and Clinical Presentation
Photokeratitis/photoconjunctivitis occurs when the cornea and conjunctiva are exposed to excessive ultraviolet radiation, most commonly from:
- Solar exposure (snow blindness)
- Artificial UV sources (welding arcs, tanning beds, laboratory UV lights)
- Reflected UV radiation from snow, water, or sand
Symptoms typically appear 6-12 hours after exposure and include:
- Severe eye pain and foreign body sensation
- Photophobia
- Excessive tearing
- Conjunctival injection (redness)
- Eyelid swelling
- Blurred vision
- Blepharospasm (eyelid spasm)
Treatment Algorithm
First-Line Management
- Remove from UV exposure immediately
- Cool compresses to reduce inflammation and provide symptomatic relief
- Preservative-free lubricating eye drops (artificial tears) every 1-2 hours to soothe the ocular surface and dilute inflammatory mediators 2
- Pain management:
- Oral analgesics (acetaminophen or NSAIDs)
- Topical NSAIDs may be considered for severe pain
Additional Treatments for Moderate to Severe Cases
- Cycloplegic agents (e.g., cyclopentolate) for ciliary spasm and pain relief in severe cases
- Antibiotic ointment may be used prophylactically if epithelial defects are present to prevent secondary infection 3
- Autologous serum eye drops (20% concentration) can be considered for cases with significant corneal nerve damage to promote neuroregeneration 3
- Short-term topical steroids (e.g., loteprednol 0.5%) may be used in severe cases with significant inflammation, but only under close ophthalmologic supervision 3
Contraindicated Treatments
- Topical anesthetics for prolonged use (can delay healing and mask worsening symptoms)
- Long-term steroid use without ophthalmologic supervision (risk of increased intraocular pressure, cataract formation, or delayed healing)
Follow-up and Monitoring
- Most cases resolve within 24-48 hours without permanent damage
- Follow-up within 24-48 hours for severe cases or if symptoms worsen
- Monitor for:
- Corneal epithelial healing
- Development of secondary infection
- Persistent visual disturbances
Special Considerations
Contact Lens Wearers
- Discontinue contact lens wear until complete resolution of symptoms and signs
- Consider new lenses after recovery to prevent contamination
- Review contact lens fit, type, and care regimen before resuming wear 2
Prevention Strategies
- Proper eye protection when exposed to UV sources (welding, tanning, snow activities)
- UV-blocking sunglasses with side shields
- Wide-brimmed hats for additional protection
- Awareness of high-risk environments (high altitude, snow, water)
Long-term Complications
Chronic UV exposure may contribute to:
- Pterygium
- Climatic droplet keratopathy
- Increased risk of ocular surface squamous neoplasia 4
When to Refer to Ophthalmology
- Visual acuity does not return to baseline within 48-72 hours
- Persistent corneal epithelial defects
- Signs of corneal infection
- Severe pain unresponsive to conventional treatment
- History of recurrent episodes
Photoconjunctivitis is typically self-limiting with appropriate supportive care, and most patients recover completely without long-term visual impairment when properly managed.