Are topical ointments more effective in warm, moist areas?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: March 9, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Guidelines

Topical ointments are not the most effective choice for warm, moist areas of the body, as they can trap moisture and heat, potentially worsening conditions like fungal infections or bacterial overgrowth. For these areas, such as skin folds, groin, armpits, and between toes, creams, lotions, or gels are typically more appropriate choices 1. Ointments have a thick, greasy base that creates an occlusive barrier on the skin, which can be beneficial for dry, scaly areas like elbows, knees, or psoriatic plaques, but not for warm, moist environments.

Some key points to consider when treating skin conditions in warm, moist areas include:

  • Using water-based products like creams or gels that allow better evaporation and are less likely to cause maceration of the skin 1
  • Keeping the area clean and dry to promote healing and prevent recurrence
  • Avoiding the use of ointments that can trap moisture and heat, potentially worsening conditions like fungal infections or bacterial overgrowth
  • Considering alternative treatments, such as calcineurin inhibitors (topical tacrolimus and topical pimecrolimus), which are helpful in the treatment of inverse psoriasis 1

It's also important to note that the treatment of skin conditions in warm, moist areas requires careful consideration of the potential risks and benefits of different treatment options. For example, the use of topical corticosteroids can be effective in reducing inflammation and itching, but can also increase the risk of irritation and toxicity in warm, moist environments 1.

In general, the treatment of skin conditions in warm, moist areas should be guided by the principles of minimizing the risk of irritation and toxicity, while also promoting healing and preventing recurrence. This can be achieved by using the appropriate medication vehicle, keeping the area clean and dry, and considering alternative treatments that are specifically designed for use in warm, moist environments 1.

From the Research

Effectiveness of Topical Ointments in Warm, Moist Areas

  • The effectiveness of topical ointments in warm, moist areas is not directly addressed in the provided studies 2, 3, 4, 5, 6.
  • However, a study on the comparison of lotions, creams, gels, and ointments for the treatment of childhood eczema found that the four emollient types were equally effective 4.
  • Another study found that ointments are believed to be more effective than creams and solutions due to their even spread on the skin 3.
  • The properties and definitions of various topical formulations, including ointments, creams, lotions, and gels, are discussed in a review, which may provide insight into their effectiveness in different skin conditions 5.
  • Moisture-associated skin damage (MASD) can result from prolonged exposure to excessive moisture, and management involves assessment, addressing the underlying cause, and implementing a structured skin care regimen 6.

Topical Ointments in Dermatology

  • Topical medications are key agents in treating a range of skin conditions, and ointments are a type of topical formulation used in dermatology 2.
  • A study on topical treatments in dermatology discusses the selection of appropriate agents, prescription of quantities, and counseling of patients on safe and effective treatment regimens, but does not specifically address the effectiveness of ointments in warm, moist areas 2.

Comparison of Topical Formulations

  • A study comparing the application and spreading of four different pharmaceutical vehicles found that ointments are spread evenly on the skin, while creams and solutions are unevenly spread 3.
  • The same study found that ointments have advantages over creams and solutions, including a more even dose and less cooling due to evaporation of formulation water/alcohol 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Topical treatments in dermatology.

British journal of hospital medicine (London, England : 2005), 2021

Research

A Guide to Topical Vehicle Formulations.

Journal of cutaneous medicine and surgery, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.