How do you calculate absorbance values from percent transmission (%T) values using a spectrophotometer?

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Calculating Absorbance Values from Percent Transmission

To calculate absorbance values from percent transmission (%T), use the formula A = -log(T), where T is the decimal form of %T (divide %T by 100). 1

Absorbance Calculation Formula

The Beer-Lambert law relates absorbance to transmittance through the following equation:

A = -log₁₀(T) = -log₁₀(%T/100)

Where:

  • A = Absorbance (no units)
  • T = Transmittance (decimal form)
  • %T = Percent Transmission

Calculations for the Given Values

Let's calculate the absorbance values for each of the provided %T values:

a. 34%T

T = 34/100 = 0.34 A = -log₁₀(0.34) = 0.4685 Absorbance = 0.47 (rounded to 2 decimal places)

b. 78%T

T = 78/100 = 0.78 A = -log₁₀(0.78) = 0.1079 Absorbance = 0.11 (rounded to 2 decimal places)

c. 21%T

T = 21/100 = 0.21 A = -log₁₀(0.21) = 0.6778 Absorbance = 0.68 (rounded to 2 decimal places)

Understanding the Relationship Between Transmission and Absorbance

The relationship between transmission and absorbance is inverse and logarithmic:

  • Higher %T values indicate that more light is passing through the sample (less absorption)
  • Lower %T values indicate that less light is passing through the sample (more absorption)
  • Absorbance values typically range from 0 (100% transmission) to 2 (1% transmission)

Applications in Spectrophotometry

This calculation is fundamental in spectrophotometric analyses used in:

  • Quantification of compounds in solution
  • Enzyme activity measurements 1
  • Determination of protein concentrations
  • Analysis of drug concentrations

Common Pitfalls to Avoid

  • Remember that absorbance has no units
  • Ensure %T is converted to decimal form before calculating absorbance
  • For accurate measurements, absorbance values should ideally fall between 0.1 and 1.0, as values outside this range may have higher measurement error
  • Always calibrate spectrophotometers properly before taking measurements to ensure accuracy

The Beer-Lambert law (A = εcl) can be used to determine concentration once absorbance is known, where ε is the molar absorptivity coefficient, c is concentration, and l is path length 1.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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