Does Procardia XL (Nifedipine) Contain Soy?
Yes, Procardia XL (nifedipine) contains soy lecithin as an inactive ingredient according to the FDA drug label. 1
Evidence from FDA Drug Label
The FDA drug label for nifedipine extended-release tablets clearly states that the formulation contains lecithin (soy) as one of the inactive ingredients. This applies to all dosage strengths:
30mg tablets contain: "lactose monohydrate, microcrystalline cellulose, hypromellose, magnesium stearate, polyvinyl alcohol, talc, titanium dioxide, macrogol/polyethylene glycol 3350, lecithin (soy), iron oxide yellow and iron oxide black" 1
60mg tablets contain: "lactose monohydrate, microcrystalline cellulose, hypromellose, magnesium stearate, polyvinyl alcohol, titanium dioxide, talc, macrogol/polyethylene glycol 3350, lecithin (soy), iron oxide red, iron oxide black and iron oxide yellow" 1
90mg tablets contain: "lactose monohydrate, microcrystalline cellulose, hypromellose, magnesium stearate, polyvinyl alcohol, iron oxide red, talc, macrogol/polyethylene glycol 3350, iron oxide yellow, titanium dioxide, lecithin (soy) and iron oxide black" 1
Clinical Implications for Patients with Soy Allergy
For patients with known soy allergies, this information is clinically significant:
- Patients with soy allergies should avoid Procardia XL due to the presence of soy lecithin
- Allergic reactions could potentially affect patient morbidity and mortality
- Alternative calcium channel blockers without soy ingredients should be considered for patients with soy allergies
Alternative Options
For patients who need a calcium channel blocker but have soy allergies:
- Consider other dihydropyridine calcium channel blockers that may not contain soy (check individual product labeling)
- Non-dihydropyridine calcium channel blockers like diltiazem or verapamil may be alternatives (though they have different pharmacological profiles) 2
- Always verify the inactive ingredients in any alternative medication
Important Considerations
- While the soy content is minimal as it's used as an excipient (inactive ingredient), even small amounts can trigger allergic reactions in sensitive individuals
- Patients should always inform healthcare providers about all allergies before starting new medications
- Pharmacists can help identify alternative medications that don't contain soy lecithin
The presence of soy in Procardia XL is clearly documented in the FDA-approved labeling and should be considered when prescribing this medication to patients with known soy allergies.