From the Guidelines
The list of Angiotensin Receptor Blockers (ARBs) includes losartan, valsartan, candesartan, irbesartan, telmisartan, olmesartan, eprosartan, and azilsartan, as stated in the most recent guideline 1. These medications are primarily used to treat hypertension, heart failure, and diabetic nephropathy. They work by selectively blocking the binding of angiotensin II to AT1 receptors in many tissues, preventing vasoconstriction, aldosterone secretion, and other effects that would raise blood pressure. Some key points to consider when using ARBs include:
- They are generally well-tolerated with fewer side effects than many other antihypertensives, though they can cause dizziness, elevated potassium levels, and should not be used during pregnancy.
- They're often prescribed as alternatives for patients who cannot tolerate ACE inhibitors due to cough or angioedema, as ARBs rarely cause these specific side effects while providing similar cardiovascular and renal protection.
- The use of ARBs to reduce morbidity and mortality is recommended in patients with prior or current symptoms of chronic HFrEF who are intolerant to ACE inhibitors because of cough or angioedema, as stated in the guideline 1.
- ARBs should be started at low doses and titrated upward, with an attempt to use doses shown to reduce the risk of cardiovascular events in clinical trials, and should be given with caution to patients with low systemic blood pressure, renal insufficiency, or elevated serum potassium (>5.0 mEq/L) 1.
From the FDA Drug Label
Losartan Potassium Tablets is a prescription medicine called an angiotensin receptor blocker (ARB) Telmisartan tablets, USP are an angiotensin II receptor blocker (ARB)
The list of Angiotensin Receptor Blockers (ARBs) mentioned in the provided drug labels includes:
From the Research
Angiotensin Receptor Blockers (ARBs)
The following is a list of Angiotensin Receptor Blockers (ARBs) mentioned in the studies:
- Azilsartan 4, 5
- Candesartan 6, 4, 7, 8, 5
- Eprosartan 6, 4, 7, 8, 5
- Irbesartan 6, 4, 7, 8, 5
- Losartan 6, 4, 7, 8, 5
- Olmesartan 4, 5
- Telmisartan 6, 4, 7, 5
- Valsartan 6, 4, 7, 8, 5
Key Characteristics of ARBs
Some key characteristics of ARBs include:
- Non-peptide compounds with varied structures 6
- Specific blockage of the AT1 receptor subtype 7
- Dose-dependent inhibition of the blood pressure response to exogenous AngII 7
- Excellent tolerability and side effect profile 7
- Differences in receptor binding kinetics, pharmacokinetics, and pharmacodynamics 8