From the Guidelines
The list of Angiotensin Receptor Blockers (ARBs) includes losartan, valsartan, irbesartan, candesartan, telmisartan, olmesartan, azilsartan, and eprosartan, as stated in the most recent guideline 1. These medications are primarily used to treat hypertension, heart failure, and diabetic nephropathy. Some key points about ARBs include:
- They work by preventing angiotensin II from binding to its receptors, thereby reducing vasoconstriction and decreasing blood pressure.
- They also inhibit aldosterone secretion, which helps reduce sodium and water retention.
- ARBs are generally well-tolerated with fewer side effects than ACE inhibitors, particularly lacking the dry cough associated with ACE inhibitors, making them good alternatives for patients who cannot tolerate ACE inhibitors.
- Typical starting doses vary:
- losartan 50-100mg daily 1
- valsartan 80-320mg daily 1
- irbesartan 150-300mg daily 1
- candesartan 8-32mg daily 1
- telmisartan 20-80mg daily 1
- olmesartan 20-40mg daily 1
- azilsartan 40-80mg daily 1
- eprosartan 600-800mg daily 1 Most ARBs are taken once daily and can be adjusted based on blood pressure response. It's worth noting that the use of ARBs has been recommended in patients with prior or current symptoms of chronic heart failure with reduced ejection fraction (HFrEF) who are intolerant to ACE inhibitors because of cough or angioedema, as stated in 1 and 1.
From the FDA Drug Label
Losartan Potassium Tablets is a prescription medicine called an angiotensin receptor blocker (ARB) Telmisartan tablets, USP are an angiotensin II receptor blocker (ARB)
The list of Angiotensin Receptor Blockers (ARBs) mentioned in the provided drug labels includes:
From the Research
Angiotensin Receptor Blockers (ARBs)
The following is a list of Angiotensin Receptor Blockers (ARBs) mentioned in the studies:
- Azilsartan 4, 5
- Candesartan 6, 4, 7, 8, 5
- Eprosartan 6, 4, 7, 8, 5
- Irbesartan 6, 4, 7, 8, 5
- Losartan 6, 4, 7, 8, 5
- Olmesartan 4, 5
- Telmisartan 6, 4, 7, 5
- Valsartan 6, 4, 7, 8, 5
Key Characteristics of ARBs
Some key characteristics of ARBs include:
- Non-peptide compounds with varied structures 6
- Specific blockage of the AT1 receptor subtype 7
- Dose-dependent inhibition of the blood pressure response to exogenous AngII 7
- Excellent tolerability and side effect profile 7
- Differences in receptor binding kinetics, pharmacokinetics, and pharmacodynamics 8