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Differential Diagnosis for Thunderclap Headache

Single Most Likely Diagnosis

  • Subarachnoid Hemorrhage (SAH): This is often considered the most likely diagnosis for a thunderclap headache due to its severity and sudden onset, which can mimic the description of a "thunderclap." SAH is a medical emergency that requires immediate attention.

Other Likely Diagnoses

  • Migraine: Although typically not as severe as a thunderclap headache, some migraines can present with sudden, severe pain. However, they usually have other accompanying symptoms such as aura, nausea, or sensitivity to light and sound.
  • Tension Headache: While less likely to be described as a thunderclap, severe tension headaches can have a rapid onset and may be considered in the differential, especially if other symptoms like neck pain or scalp tenderness are present.
  • Cluster Headache: Known for their severe, unilateral pain, cluster headaches can start suddenly and reach maximum intensity within minutes, potentially fitting the thunderclap description.

Do Not Miss Diagnoses

  • Subarachnoid Hemorrhage (SAH): Already mentioned, but crucial enough to reiterate due to its high morbidity and mortality if missed.
  • Cervical Artery Dissection: This condition involves a tear in the wall of one of the arteries in the neck, which can lead to a stroke. It often presents with sudden, severe headache and neck pain.
  • Venous Sinus Thrombosis: A blood clot in the venous sinuses of the brain can cause a sudden, severe headache, among other symptoms. It's a rare but potentially life-threatening condition.
  • Pituitary Apoplexy: A condition where there is sudden hemorrhage or infarction of the pituitary gland, leading to severe headache, visual disturbances, and potentially life-threatening hormonal imbalances.

Rare Diagnoses

  • Reversible Cerebral Vasoconstriction Syndrome (RCVS): Characterized by sudden, severe headaches and reversible vasoconstriction of the cerebral arteries, often without an identifiable cause.
  • Primary Thunderclap Headache: A rare condition where the headache is the only symptom, and no underlying cause can be found despite extensive investigation.
  • Colloid Cyst: A rare, benign brain tumor that can cause obstructive hydrocephalus, leading to sudden increases in intracranial pressure and severe headache.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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