Is genetic testing available for Multiple Sclerosis (MS)?

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From the Research

Genetic Testing for Multiple Sclerosis (MS)

  • Genetic testing for MS is not a straightforward process, as the disease is influenced by both genetic and environmental factors 1, 2.
  • While numerous genetic associations have been identified, they only explain up to half of the disease's heritability, leaving room for further research 2, 3.
  • Current genetic studies have identified several genes associated with MS, including HLA classes I and II, T-cell receptor beta, CTLA4, ICAM1, and SH2D2A 3, 4.
  • The use of genetic testing in MS diagnosis and management is limited, and it is not currently possible to translate genetic discoveries into a widely available genetic test to diagnose MS or recognize family members at risk of developing MS 5.
  • Researchers continue to explore the genetic contributions to MS susceptibility and progression, with the goal of improving diagnosis and treatment options 1, 2, 5.

References

2
Research

Genetic and gene expression signatures in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England), 2020

3
Research

The genetics of multiple sclerosis.

Results and problems in cell differentiation, 2010

4
Research

Genetics of multiple sclerosis.

The Lancet. Neurology, 2004

5
Research

The genetics of multiple sclerosis.

Practical neurology, 2012

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