From the Research
Cresemba (isavuconazonium sulfate) has not been specifically associated with pill esophagitis based on available clinical data. Pill esophagitis occurs when medications become lodged in the esophagus and cause irritation or damage to the esophageal lining. While Cresemba is a large capsule, reports of it causing esophagitis are uncommon in medical literature. However, as with any oral medication, proper administration techniques can minimize risk.
Key Considerations
- Patients should take Cresemba with a full glass of water (at least 8 ounces) while sitting upright or standing, and remain upright for at least 10 minutes afterward to ensure the medication passes completely through the esophagus into the stomach.
- If you experience symptoms such as chest pain, painful or difficult swallowing after taking Cresemba, contact your healthcare provider promptly.
- These precautions are particularly important for patients with pre-existing esophageal disorders or difficulty swallowing.
Supporting Evidence
- A study published in the Canadian journal of gastroenterology & hepatology in 2016 1 highlights the importance of clinician awareness for drug-associated esophageal injury and the value of prophylaxis against this condition by universally recommending drinking enough water in an upright position during ingestion of any oral medication.
- Another study published in The Turkish journal of gastroenterology in 2014 2 found that almost every kind of drug, particularly doxycycline, can cause ulcer in the esophagus, and that pill esophagitis can be prevented by warning patients about drinking water sufficiently and sitting up while taking the pill.
Administration Techniques
- To minimize the risk of pill esophagitis, patients should be instructed to take Cresemba with a full glass of water and remain upright for at least 10 minutes afterward.
- Patients with pre-existing esophageal disorders or difficulty swallowing should be closely monitored and instructed on proper administration techniques to minimize the risk of pill esophagitis.