Immediate Management of Venomous Snakebites
The immediate management of a snakebite should include calling emergency services, immobilizing the affected limb, removing constricting jewelry, and avoiding harmful interventions such as tourniquets, ice application, or wound incision/suction. 1
Initial Assessment and First Aid
Call emergency services immediately 1
- This is the most critical first step for all suspected venomous snakebites
Rest and immobilize the bitten extremity 1
- Keep the affected limb below heart level to reduce venom spread
- Immobilization helps limit systemic venom distribution
Remove rings and other constricting jewelry from the affected limb 1
- This prevents complications from potential swelling
Apply pressure immobilization bandage (40-70 mmHg for upper extremity, 55-70 mmHg for lower extremity) 1
- Important exception: Do NOT use pressure immobilization for North American pit viper bites
Avoid harmful interventions that have no clinical benefit and may worsen injury: 1, 2
- Do NOT apply ice
- Do NOT use suction devices (except possibly venom extractor within first 5 minutes) 3
- Do NOT apply electric shock
- Do NOT apply tourniquets
- Do NOT make incisions into the bite
- Do NOT attempt mouth suction
Hospital-Based Management
Once at a medical facility, management should include:
Laboratory assessment 1
- Complete blood count
- Coagulation studies
- Renal function tests
- Electrolytes
Monitoring 1
- Cardiac monitoring
- Oxygen saturation (provide supplemental oxygen if hypoxic)
- Signs of hemolysis, anemia, coagulopathy, and acute kidney injury
- The mainstay of treatment for venomous snakebites
- Should be administered in a hospital setting with monitoring for adverse reactions
- Options include:
- Equine-derived antivenin (traditional standard of care)
- Sheep-derived antigen binding fragment ovine (CroFab) - less allergenic
- Most effective when given within four hours of the snakebite 4
Supportive care 1
- Pain management
- Prophylactic antibiotics if indicated for wound infection
- Tetanus prophylaxis if needed
Severity Assessment
Snakebite severity can be graded to guide treatment: 2, 3
- No intoxication ("dry" bite)
- Mild intoxication (local edema and pain)
- Moderate intoxication (pain, edema spreading beyond bite zone, systemic signs)
- Severe intoxication (shock, severe coagulopathy, massive edema)
Special Considerations
- Compartment syndrome: Rarely develops but requires close monitoring of the extremity via serial physical examination and measurement of compartment pressure 5
- Pregnant patients: Should receive similar treatment to non-pregnant individuals, including appropriate antivenom when indicated 1
- Patients with sickle cell disease: Require close monitoring for vaso-occlusive crisis triggered by envenomation 1
Common Pitfalls to Avoid
- Delayed seeking of medical attention: Antivenom is most effective when administered within 4 hours 4
- Inappropriate first aid: Traditional methods like suction, incision, and tourniquets can worsen outcomes 1, 2
- Underestimating severity: Even seemingly minor bites can progress to serious envenomation 6
- Overlooking hypersensitivity: Patients must be tested for hypersensitivity before receiving antivenin 4