From the Research
L-theanine should not be used as a primary treatment for seizure disorders due to its limited and inconsistent evidence supporting its anticonvulsant properties, and its potential to decrease the threshold for generalized seizures, as shown in a study published in 2013 1. The effect of L-theanine on seizure activity is complex and not fully understood, with some studies suggesting it may have mild anticonvulsant properties, while others indicate it may actually decrease the threshold for generalized seizures.
- Typical supplemental doses of L-theanine range from 100-400mg daily, with some people taking it divided into 2-3 doses throughout the day.
- However, the interaction between L-theanine and anticonvulsant medications is not well-studied, and its use as a complementary approach should be discussed with a neurologist first, without discontinuing prescribed anticonvulsant medications.
- Established anticonvulsant medications have significantly stronger evidence for seizure control and should remain the foundation of any seizure management plan.
- A more recent review published in 2025 2 highlights the limited evidence supporting the use of L-theanine for brain health and relaxation, and urges caution in its use as a supplement, which further supports the recommendation to prioritize established anticonvulsant medications for seizure management.
- Other studies have investigated the effects of L-theanine on cognitive function, anxiety, and stress, but these findings are not directly relevant to its use in seizure management, and should not influence the decision to use established anticonvulsant medications as the primary treatment for seizure disorders.