What is the recommended treatment and postoperative care for a 47-year-old male undergoing scrotal sebaceous cyst removal?

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Management of Scrotal Sebaceous Cyst Removal

Complete surgical excision with minimal incision technique is the recommended treatment for scrotal sebaceous cysts, followed by proper wound care including keeping the area clean and dry, applying antibiotic ointment, and monitoring for signs of infection during the healing period. 1, 2

Preoperative Assessment and Preparation

  • Diagnostic confirmation: Duplex Doppler ultrasound is recommended to confirm diagnosis and rule out other causes of scrotal pathology such as varicocele, hydrocele, testicular torsion, or tumors 1
  • Skin preparation: Chlorhexidine-alcohol skin preparation should be used before the procedure to prevent surgical site infection 3
  • Antimicrobial prophylaxis: A single dose of antimicrobial prophylaxis should be administered 1 hour before skin incision 3

Surgical Technique Options

  1. Minimal incision technique (preferred approach):

    • Small incision (2-3mm) made directly over the cyst
    • Removal of cyst contents followed by complete excision of the cyst wall
    • Associated with extremely low recurrence rates (0.66%) and excellent cosmetic results 2
  2. Two-step procedure (for large or cosmetically sensitive cysts):

    • First step: Small opening to drain cyst contents
    • Second step: Complete excision of cyst wall approximately 1 month later
    • Particularly useful for large cysts or those in areas of cosmetic concern 4
  3. Complete excision (traditional approach):

    • Removal of the entire cyst including the wall in one procedure
    • Necessary when multiple cysts cover extensive areas of scrotal skin 5

Postoperative Care

  • Wound care: Keep the surgical site clean and dry
  • Pain management: Multimodal approach including:
    • NSAIDs for pain and inflammation
    • Scrotal support to minimize discomfort
    • Cold compresses to reduce swelling 1
  • Activity modification: Avoid strenuous physical activity for 1-2 weeks
  • Follow-up: Evaluation at 1-2 weeks post-procedure to assess healing

Potential Complications and Management

  • Infection: Monitor for increased pain, redness, swelling, or purulent discharge
    • If infection develops, consider oral antibiotics effective against skin flora
  • Recurrence: Complete excision of the cyst wall is essential to prevent recurrence 2
  • Scarring: Minimal incision techniques help reduce visible scarring 2, 4

Special Considerations

  • Multiple cysts: When multiple sebaceous cysts cover the entire scrotum, complete excision of all cysts may be necessary 5
  • Alternative techniques: For patients concerned about scarring, laser techniques may be considered, though these are less commonly used 6

When to Refer to a Specialist

  • Multiple or very large cysts
  • Recurrent cysts after previous excision
  • Signs of infection or inflammation
  • Uncertainty about diagnosis
  • Cysts with atypical features that raise concern for malignancy 3

Remember that proper histological examination of excised tissue is important to confirm diagnosis and rule out rare malignant transformation 3.

References

Guideline

Conservative Management of Scrotal Pain

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Research

Sebaceous cyst excision with minimal surgery.

American family physician, 1990

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

[Nd-YAG laser photocoagulation of scrotal sebaceous cysts].

Actas urologicas espanolas, 2002

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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