What is the step-by-step process for interpreting an Electrocardiogram (EKG)?

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Last updated: September 1, 2025View editorial policy

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Systematic Approach to ECG Interpretation

A systematic approach to ECG interpretation is essential for accurate diagnosis, with all ECGs requiring verification by a qualified physician regardless of computer interpretation, as incorrect readings can significantly impact patient morbidity and mortality. 1

Step 1: Assess Rate and Rhythm

  • Heart Rate: Count the number of QRS complexes in a 6-second strip and multiply by 10
    • Normal: 60-100 beats/min
    • Bradycardia: <60 beats/min
    • Tachycardia: >100 beats/min 1
  • Rhythm: Evaluate regularity of R-R intervals
    • Check for P waves before each QRS complex
    • Assess if P waves are uniform in morphology
    • Determine if PR interval is constant

Step 2: Evaluate Intervals and Durations

  • PR Interval: Measure from beginning of P wave to beginning of QRS complex
    • Normal: 120-200 ms (3-5 small squares)
    • Prolonged PR (>200 ms): First-degree AV block
    • Short PR (<120 ms): Pre-excitation syndromes 1
  • QRS Duration: Measure width of QRS complex
    • Normal: <120 ms (3 small squares)
    • Widened QRS (≥120 ms): Bundle branch blocks, ventricular rhythms 1
  • QT Interval: Measure from beginning of QRS to end of T wave
    • Calculate corrected QT (QTc) for heart rate
    • Normal QTc: <450 ms in men, <460 ms in women 1

Step 3: Analyze Axis and Voltage

  • Determine Electrical Axis:
    • Normal axis: -30° to +90°
    • Left axis deviation: -30° to -90°
    • Right axis deviation: +90° to +180°
    • Extreme axis deviation: -90° to ±180°
  • Check for Hypertrophy:
    • Left ventricular hypertrophy: Sokolow-Lyon criteria (S in V1 + R in V5 or V6 >35 mm) or Cornell criteria (R in aVL + S in V3 >28 mm for men, >20 mm for women) 1
    • Right ventricular hypertrophy: R in V1 >7 mm or R/S ratio in V1 >1 1

Step 4: Examine ST Segments and T Waves

  • ST Segment Evaluation:
    • ST elevation: ≥0.1 mV (1 mm) in all leads except V2-V3
    • For V2-V3: ≥0.2 mV (2 mm) in men ≥40 years, ≥0.25 mV in men <40 years, ≥0.15 mV in women 2
    • ST depression: ≥0.05 mV (0.5 mm) in two contiguous leads
  • T Wave Assessment:
    • Normal T wave: Upright in leads I, II, V3-V6; inverted in aVR
    • T wave inversion: May indicate ischemia, strain, or normal variant 2
    • T wave alternans: Alternating T wave amplitude, may indicate electrical instability 2

Step 5: Look for Signs of Ischemia/Infarction

  • Identify location based on lead groups:
    • Anterior: V1-V4
    • Lateral: I, aVL, V5-V6
    • Inferior: II, III, aVF
    • Posterior: Tall R waves and ST depression in V1-V2 1
  • Look for pathological Q waves: >40 ms or >25% of R wave amplitude 1
  • Assess for evolving changes: Hyperacute T waves, ST elevation, Q waves, T wave inversion

Step 6: Identify Additional Abnormalities

  • Conduction Abnormalities:
    • AV blocks: First-degree, second-degree (Mobitz I/II), third-degree
    • Bundle branch blocks: RBBB, LBBB
    • Fascicular blocks: Left anterior/posterior fascicular block
  • Chamber Enlargement:
    • Atrial enlargement: P wave abnormalities
    • Ventricular hypertrophy: Voltage criteria and repolarization changes
  • U Wave Abnormalities: Most evident in leads V2 and V3, abnormal if prominent 2

Common Pitfalls to Avoid

  1. Relying solely on computer interpretation: Computer algorithms have significant error rates (40.7% for acute MI, 75% for high-degree AV blocks) 1
  2. Misplacement of electrodes: Especially V1/V2 placed too high, leading to false patterns 1
  3. Failure to compare with previous ECGs: Serial changes are often more important than a single tracing
  4. Ignoring clinical context: ECG findings must be interpreted in light of the patient's clinical situation 1
  5. Pattern recognition without understanding: Focus on understanding pathophysiology rather than memorizing patterns 1

Maintaining Competency

  • Interpret at least 500-800 ECGs under supervision to develop competency 1
  • Maintain proficiency by interpreting at least 100 ECGs yearly 1
  • Participate in continuing education and workshops to improve interpretation skills 1

By following this systematic approach, clinicians can improve their accuracy in ECG interpretation, leading to better clinical decisions and improved patient outcomes.

References

Guideline

Electrocardiography Guidelines

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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