What is the typical dosage for glutathione (Glutathione) subcutaneous injections?

Glutathione Subcutaneous Injection Dosage

Based on available evidence, the typical dosage for glutathione subcutaneous injections ranges from 600-1500 mg per administration, though there are no standardized guidelines specifically for subcutaneous glutathione use.

Evidence for Glutathione Dosing

The available clinical evidence primarily focuses on intravenous glutathione administration rather than subcutaneous injections. From the clinical trials examining glutathione's efficacy:

• Studies used doses ranging from 1500-2500 mg for intravenous administration 1
• Specific dosages included:
  • 2.5g over 15 minutes 1
  • 1500 mg/m² in 100 mL of saline over a 15-minute period 1
  • 3 g/m² infused over 20 minutes 1
  • 5g immediately before certain treatments 1

Considerations for Subcutaneous Administration

When adapting intravenous dosing to subcutaneous administration, several factors should be considered:

• Subcutaneous administration typically requires smaller volumes than IV administration
• Bioavailability may differ between routes of administration
• The absorption rate is generally slower with subcutaneous administration

Dosing Algorithm

1. Starting dose recommendation:

   • For adults: 600-1000 mg per subcutaneous injection
   • For smaller individuals (<60kg): Consider starting at the lower end of the range

2. Administration frequency:

   • Typically administered 1-3 times weekly based on clinical response
   • For acute conditions: May be administered daily for short periods

3. Preparation and administration:

   • Dilute glutathione powder in appropriate diluent immediately before injection
   • Compatible with 0.9% saline, 5% glucose solution, and most IV solutions 2
   • Avoid solutions containing sodium bisulfite due to potential interference 2

Monitoring and Safety

• Monitor for local injection site reactions
• Glutathione is generally well-tolerated but may cause:
  • Skin rash
  • Headache
  • Gastrointestinal discomfort
  • Rarely, allergic reactions

Special Considerations

• Skin lightening effects: Glutathione has been studied for skin lightening effects, with some evidence suggesting efficacy at doses of 250-500 mg/day orally 3, 4
• Chemotherapy-induced neuropathy: Higher doses (1500-2500 mg) have been studied for prevention of chemotherapy-induced neuropathy 1, 5
• G6PD deficiency: Consider testing for G6PD deficiency before administration, as glutathione may potentially cause similar concerns as other reducing agents 1

Limitations of Evidence

• Most studies focus on intravenous rather than subcutaneous administration
• Limited standardized guidelines exist for subcutaneous glutathione use
• Long-term safety data for regular subcutaneous administration is lacking
• Clinical outcomes and optimal dosing schedules remain to be established

Clinical Perspective

While glutathione supplementation shows potential benefits in certain conditions, the evidence for subcutaneous administration specifically is limited. Oral supplementation has been shown to increase body stores of glutathione 6, which may be a safer alternative to injectable forms for some patients.