From the FDA Drug Label
Since collagen accounts for 75% of the dry weight of skin tissue, the ability of collagenase to digest collagen in the physiological pH and temperature range makes it particularly effective in the removal of detritus. Collagen in healthy tissue or in newly formed granulation tissue is not attacked.
The effects of Xiaflex (collagenase clostridium histolyticum) injections into the fifth finger are not directly stated in the provided drug labels. Key points:
- The drug labels discuss the general mechanism of action of collagenase clostridium histolyticum.
- There is no specific information about injections into the fifth finger. 1
From the Research
Xiaflex (collagenase clostridium histolyticum) injections into the fifth finger are a safe and effective treatment option for Dupuytren's contracture, with a success rate of 70% and a recurrence rate of 25% 2. The treatment involves injecting Xiaflex into the palmar cord, followed by finger manipulation to break the contracted cord.
- The typical dose for the pinky finger is 0.58 mg per injection.
- The procedure is performed in a doctor's office without general anesthesia.
- After treatment, patients should follow a specific finger exercise regimen and may need to wear a splint at night for up to four months.
- Side effects commonly include swelling, bruising, pain, and temporary limitation in finger movement.
- Multiple treatment cycles may be necessary for severe contractures. However, it's essential to note that there is a risk of tendon rupture, as reported in a case study where a patient experienced acute double flexor tendon rupture after Xiaflex injection into the little finger 3. The most recent and highest quality study on this topic is a longitudinal assessment of Dupuytren's contracture recurrence and treatment following collagenase clostridium histolyticum injection, which found that the treatment is safe and effective, with a success rate of 70% and a recurrence rate of 25% 2. Other studies have also reported similar results, with a study published in 2019 finding that collagenase injections are a viable treatment for Dupuytren's contracture, with a success rate of 48% and a mean improvement in flexion contracture of 40° 4. Overall, Xiaflex injections are a valuable treatment option for Dupuytren's contracture affecting the pinky finger, offering a non-surgical alternative with a high success rate and minimal side effects 2, 4.