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Differential Diagnosis for Painless and Painful Vaginal Bleeding in Pregnancy

Single Most Likely Diagnosis

  • Threatened abortion or miscarriage: This is the most common cause of vaginal bleeding in early pregnancy, especially if the bleeding is painful. It occurs when there is a risk of miscarriage but the cervix is still closed.

Other Likely Diagnoses

  • Placenta previa: A condition where the placenta partially or completely covers the cervix, leading to painless vaginal bleeding, typically in the second or third trimester.
  • Placental abruption: A condition where the placenta separates from the uterus, causing painful vaginal bleeding and potentially compromising fetal health.
  • Ectopic pregnancy: A pregnancy that develops outside the uterus, often presenting with painful vaginal bleeding and abdominal pain.

Do Not Miss Diagnoses

  • Uterine rupture: A life-threatening condition where the uterus tears, often causing severe abdominal pain and vaginal bleeding. This is more common in women with a history of uterine surgery, including cesarean deliveries.
  • Molar pregnancy: A rare condition where a non-viable fertilized egg implants in the uterus, leading to abnormal growth and potentially causing vaginal bleeding.
  • Vaginal or cervical trauma: Any injury to the vagina or cervix can cause bleeding, which may be painful depending on the severity and location of the trauma.

Rare Diagnoses

  • Vasa previa: A condition where fetal blood vessels are present in the membranes covering the cervix, at risk of rupture and severe fetal hemorrhage, typically presenting with painless vaginal bleeding.
  • Uterine artery pseudoaneurysm: A rare condition that can cause vaginal bleeding due to a false aneurysm of the uterine artery, potentially life-threatening if not recognized and treated.
  • Choriocarcinoma: A rare type of cancer that can develop in the uterus during pregnancy, causing abnormal vaginal bleeding among other symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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